Lubrication of Direct-Compressible Blends with Magnesium Stearate Monohydrate and Dihydrate - Pharmaceutical Technology

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Lubrication of Direct-Compressible Blends with Magnesium Stearate Monohydrate and Dihydrate
The influence of magnesium stearate (MgSt) on powder lubrication and finished solid-dose properties presents big challenges to drug manufacturers.


Pharmaceutical Technology


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5. A. Stallings, "Approach to Understanding Immediate Release Dosage Form Dissolution Failures due to Effects of Magnesium Stearate in Pharmaceutical Formulations," AAPS poster W4332 (2005).

6. A. Alexander et al., "Characterization of the Performance of Bin Blenders: Part 3 of 3—Cohesive Powders," Pharm. Technol. 28 (9), 54–74 (2004).

7. D. Wurster, S. Likitlersuang, and Y. Chen, "The Influence of Magnesium Stearate on the Hiestand Tableting Indices and Other Related Mechanical Properties of Maltodextrins," J. Pharm. Dev. Technol. 10 (4), 461–466 (2005).

8. V. Swaminathan and D. Kildsig, "An Examination of the Moisture Sorption Characteristics of Commercial Magnesium Stearate," AAPS PharmSciTech 2 (4), article 28 (2001).

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10. S. Wu, Effects of Magnesium Stearate Hydrates on Powder Flowability, Tablet Ease, and Tablet Quality, Technical Report (Tyco Healthcare–Mallinkrodt, 2006).

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13. M. Emanuel and P. Okoye, "Evaluation of a Simple Fluid-bed Dryer Sampler Modification for On-line Profiling and End-Point Determination Utilizing Effusivity," AAPS abstract T3308 (2006).

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21. FDA, Guidance for Industry: Dissolution Testing for Immediate Release Solid Oral Dosage Forms, (FDA, Rockville, MD), http://www.fda.gov/cder/guidance/, 1997, accessed Aug. 10, 2007.


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