Advances in Asymmetric Synthesis - Pharmaceutical Technology

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Advances in Asymmetric Synthesis
Researchers forward approaches for catalytic hydroformylation, asymmetric hydrogenation, and biocatalysis to achieve enantioselectivity.


Pharmaceutical Technology


4. K. Nozaki, "Hydrocarbonylation of Carbon-Carbon Double Bonds," in Comprehensive Asymmetric Catalysis, E.N. Jacobsen, A. Pfaltz, and H. Yamamoto, Eds. (Springer, Berlin, 1999), Vol. 1, pp. 382–409.

5. K. Nozaki, H. Takaya, and T. Hiyama, "Enantioselective Hydroformylation of Olefins Catalyzed by Rhodium(I) Complexes of Chiral Phosphine–Phosphite Ligands, Topics in Catalysis 4 (3–4), 175–185 (1997).

6. C.R. Landis et al., "Highly Active, Regioselective, and Enantioselective Hydroformylation with Rh Catalysts Ligated by Bis-3,4-diazaphospholanes," J. Am. Chem. Soc. 127 (14), 5040–5042 (2005).

7. C.J. Cobley et al., "Parallel Ligand Screening on Olefin Mixtures in Asymmetric Hydroformylation Reactions," Org. Lett. 6 (19), 3277–3280 ( 2004).

8. C.J. Cobley et al., "Synthesis and Application of a New Bisphosphite Ligand Collection for Asymmetric Hydroformylation of Allyl Cyanide," J. Org. Chem. 69 (12), 4031–4040 (2004).

9. A.T. Axtell et al., "Highly Regio- and Enantioselective Asymmetric Hydroformylation of Olefins Mediated by 2,5-Disubstituted Phospholane Ligands," Ange. Chem. Int. Ed. 44 (36), 5834–5838 (2005).

10. P.J. Thomas et al., "Asymmetric Hydroformylation of Vinyl Acetate: Application in the Synthesis of Optically Active Isoxazolines and Imidazoles," Org. Lett. 9 (18), 2665– 2668 (2007).

11. C.R. Landis et al., "Rapid Access to Diverse Arrays of Chiral 3,4-Diazaphospholanes," Ange. Chem. Int. Ed. 40 (18), 3432–3434 (2001).

12. T.P. Clark, et al.,"Resolved Chiral 3,4-Diazaphospholanes and their Application to Catalytic Asymmetric Allylic Alkylation," J. Am. Chem. Soc. 125 (39), 11792–11793 (2003).

13. C.R. Landis and T.P. Clark, "Solid-Phase Synthesis of Chiral 3,4-Diazaphospholanes and their Application to Catalytic Asymmetric Allylic Alkylation," Proc. Nat. Acad. Sci. U.S.A. 101 (15), 5428–5428 (2004).

14. C.R. Landis, et al., "Synthesis, Characterization, and Transition-Metal Complexes of 3,4-Diazaphospholane Organometallics 25 (21) 1377–1391 (2006).

15. A.T. Axtell, J.Klosin, and K.A. Abboud, "Evaluation of Asymmetric Hydrogenation Ligands in Asymmetric Hydroformylation Reactions: Highly Enantioselective Ligands Based on Bis-phosphacycles," Organo-metallics 25 (21), 5003–5009 (2006).

16. Y. Yan and X. Zhang, "A Hybrid Phosphorus Ligand for Highly Enantioselective Asymmetric Hydroformylation," J. Am. Chem. Soc 128 (22), 7198–7202 (2006).

17. S. Singh et al., "Development of a Large-Scale Stereoselective Process for (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine Hydrochloride," Org. Process Res.Dev. 11 (4) 726–730 (2007).


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