Converting Intravenous Dosing to Subcutaneous Dosing With Recombinant Human Hyaluronidase - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Converting Intravenous Dosing to Subcutaneous Dosing With Recombinant Human Hyaluronidase
The preferred route of administration for an injected therapeutic agent is subcutaneous (SC), but SC injections are generally limited to no more than 1-2 mL in volume, representing a major challenge, especially for large protein biologics.


Pharmaceutical Technology


18. F. Duran Reynals, "Exaltation de l'Activité du Virus Vaccinal Par les Extraits de Certains Organes," Comptes Rendus Hebdomadaires de Séances et Mémoires de la Société de Biologie. 99, 6–7 (1928).

19. A. Claude and F. Duran-Reynals, "Chemical Properties of the Non-purified Spreading Factor from Testicle," J Exp Med. 65 (5), 661–670 (1937).

20. F. Duran-Reynals, "A Spreading Factor in Certain Snake Venoms and its Relation to their Mode of Action," J. Exp. Med. 69 (1), 69–81 (1939).

21. K. Meyer, "Hyaluronidases," in: The Enzymes, P.D. Boyer Ed., (Academic Press, New York, NY, 3rd edition, 1971), pp. 307–320.

22. K. Meyer, P. Hoffman, and A. Linker, "Hyaluronidases," in The Enzymes, P.D. Boyer, H. Lardy, and K. Myrback, Eds. (Academic Press, New York, NY, 2nd ed., 1960), pp.447–460.

23. R.G. Williams, "The Effects of Continuous Local Injection of Hyaluronidase on Skin and Subcutaneous Tissue in Rats," Anat. Rec. 122 (3), 349–361 (1955).

24. K. Pillwein et al., "Hyaluronidase Additional to Standard Chemotherapy Improves Outcome for Children with Malignant Brain Tumors," Cancer Lett. 131 (1), 101–108 (1998).

25. A.H. Eberhart, C.R. Weiler, and J.C. Erie, "Angioedema Related to the Use of Hyaluronidase in Cataract Surgery," Am. J. Ophthalmol. 138 (1), 142–143 (2004).

26. R.A. Harrison and S.J. Gaunt, "Multiple Forms of Ram and Bull Sperm Hyaluronidase Revealed by Using Monoclonal Antibodies," J. Reprod. Fertil. 82 (2), 777–785 (1988).

27. R.A. Harrison, "Hyaluronidase in Ram serum. Quantitative Determination and Isolation of Multiple Forms," Biochem J. 252 (3), 865–874 (1988).

28. H.Tint and R. Bogash (American Home Products), "Hyaluronidase," US Patent 2676139, Sept. 1, 1950.

29. H.E. Alburn et al. (American Home Products), "Stabilized Hyaluronidase Solution Containing Calcium Chloride, US Patent 2795529, June 11, 1957.

30. C.L. Borders and M.A. Raftery, "Purification and Partial Characterization of Testicular Hyaluronidase," J. Biol. Chem. 243 (13), 3756–3762 (1968).

31. W.F. Lathrop et al., "cDNA Cloning Reveals the Molecular Structure of a Sperm Surface Protein, PH-20, Involved in Sperm-egg Adhesion and the Wide Distribution of its Gene among Mammals,"J. Cell. Biol. 111 (6 Pt 2), 2939–2949 (1990).

32. M. Gmachl and G. Kreil, "Bee Venom Hyaluronidase is Homologous to a Membrane Protein of Mammalian Sperm," Proc. Natl. Acad. Sci. USA 90 (8), 3569–3573 (1993).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
24%
Oversee medical treatment of patients in the US.
12%
Provide treatment for patients globally.
10%
All of the above.
44%
No government involvement in patient treatment or drug development.
10%
Jim Miller Outsourcing Outlook Jim MillerCMO Industry Thins Out
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerFluorination Remains Key Challenge in API Synthesis
Marilyn E. Morris Guest EditorialMarilyn E. MorrisBolstering Graduate Education and Research Programs
Jill Wechsler Regulatory Watch Jill Wechsler Biopharma Manufacturers Respond to Ebola Crisis
Sean Milmo European Regulatory WatchSean MilmoHarmonizing Marketing Approval of Generic Drugs in Europe
FDA Reorganization to Promote Drug Quality
FDA Readies Quality Metrics Measures
New FDA Team to Spur Modern Drug Manufacturing
From Generics to Supergenerics
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Source: Pharmaceutical Technology,
Click here