Strategy for the Prediction and Selection of Drug Substance Salt Forms - Pharmaceutical Technology

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Strategy for the Prediction and Selection of Drug Substance Salt Forms
Through consideration of the ionic equilibria of acids and bases, one may readily calculate the formation constant of a salt species solely on the basis of knowledge of the pKA value of the acid and the pKB value of the base.


Pharmaceutical Technology


16. J.D Higgins et al., "Ibuprofen," in Analytical Profiles of Drug Substances and Excipients, vol. 27, H.G. Brittain, Ed. (Academic Press, San Diego, CA, 2001), pp. 265–300.


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