Evaluating Mucilage from Aloe Barbadensis Miller as a Pharmaceutical Excipient for Sustained-Release Matrix Tablets - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Evaluating Mucilage from Aloe Barbadensis Miller as a Pharmaceutical Excipient for Sustained-Release Matrix Tablets
Natural gums and mucilage have been widely explored as pharmaceutical excipients. The goal of this study was to extract mucilage from the leaves of Aloe barbadensis Miller and to study its functionality as an excipient in pharmaceutical sustained-release tablet formulations.


Pharmaceutical Technology


Preparation and characterization of matrix tablets.To study the matrix-forming properties of the mucilage, tablets were prepared using diclofenac sodium as a model drug and different ratios of dried mucilage powder (see Table I). Different batches of tablets were prepared (A1 to A4). The tablets containing 100 mg of diclofenac sodium were prepared by direct compression on a rotary tablet machine. The batch size was 50 g. The turret was rotated at a fixed speed of 30 rpm. Tablets were prepared using a 10-station rotary tablet machine (Minipress II, Karnavati Engineering, Ahmedabad, India) and evaluated for the following parameters: hardness, friability, and uniformity of weight (22).


Table I: Formulation of diclofenac sodium matrix tablets by the direct-compression method.
Hardness and friability test. Hardness and friability were determined using a Monsanto hardness tester and Roche friability tester, respectively.

Uniformity of weight. Twenty tablets were weighed individually, and the average weight was calculated.




Tablet swelling index. Tablets of equal weight were immersed in 50 mL of distilled water on a watch glass. At specific time intervals, tablets were carefully removed from the watch glass and blotted with filter paper to remove the water present on their surface and weighed accurately. The experiment was performed for 5 h. The swelling index was calculated using the following formula (23):

Radial and axial swelling of the tablet. The initial diameter and height of the tablet were measured, and the tablet was stored in distilled water. The increase in diameter and height were measured at selected time intervals up to 5 h. The equilibrium degree of swelling (Q) was calculated from the radial and axial swelling ratio using the following equation:




in which Vt and Vo are the tablet volumes, Rt and Ro are the radii, and It and Io are the heights at time t and zero, respectively (24).

Dissolution-rate study. In vitro drug-dissolution studies were conducted using the USP Type II apparatus (Model TDL-08, Electrolab India, Mumbai) at 50 rpm in distilled water at 37 0.5 C. At specified intervals, 5-mL samples were withdrawn and replaced with fresh medium to keep a constant volume. After appropriate dilution, the sample solutions were analyzed using a UV-visible spectrophotometer (Shimadzu, Kyoto, Japan, Shimadzu-1700) at 276 nm.The amount of drug released was determined by reference to a calibration curve constructed in the three sets of same dissolution media. The mean of the three determinations was used for the data analysis (25).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
27%
Breakthrough designations
9%
Protecting the supply chain
41%
Expedited reviews of drug submissions
9%
More stakeholder involvement
14%
View Results
Jim Miller Outsourcing Outlook Jim Miller Health Systems Raise the Bar on Reimbursing New Drugs
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerThe Mainstreaming of Continuous Flow API Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler Industry Seeks Clearer Standards for Track and Trace
Siegfried Schmitt Ask the Expert Siegfried SchmittData Integrity
Sandoz Wins Biosimilar Filing Race
NIH Translational Research Partnership Yields Promising Therapy
Clusters set to benefit from improved funding climate but IP rights are even more critical
Supplier Audit Program Marks Progress
FDA, Drug Companies Struggle with Compassionate Use Requests
Source: Pharmaceutical Technology,
Click here