Evaluating Mucilage from Aloe Barbadensis Miller as a Pharmaceutical Excipient for Sustained-Release Matrix Tablets - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Evaluating Mucilage from Aloe Barbadensis Miller as a Pharmaceutical Excipient for Sustained-Release Matrix Tablets
Natural gums and mucilage have been widely explored as pharmaceutical excipients. The goal of this study was to extract mucilage from the leaves of Aloe barbadensis Miller and to study its functionality as an excipient in pharmaceutical sustained-release tablet formulations.


Pharmaceutical Technology


Preparation and characterization of matrix tablets.To study the matrix-forming properties of the mucilage, tablets were prepared using diclofenac sodium as a model drug and different ratios of dried mucilage powder (see Table I). Different batches of tablets were prepared (A1 to A4). The tablets containing 100 mg of diclofenac sodium were prepared by direct compression on a rotary tablet machine. The batch size was 50 g. The turret was rotated at a fixed speed of 30 rpm. Tablets were prepared using a 10-station rotary tablet machine (Minipress II, Karnavati Engineering, Ahmedabad, India) and evaluated for the following parameters: hardness, friability, and uniformity of weight (22).


Table I: Formulation of diclofenac sodium matrix tablets by the direct-compression method.
Hardness and friability test. Hardness and friability were determined using a Monsanto hardness tester and Roche friability tester, respectively.

Uniformity of weight. Twenty tablets were weighed individually, and the average weight was calculated.




Tablet swelling index. Tablets of equal weight were immersed in 50 mL of distilled water on a watch glass. At specific time intervals, tablets were carefully removed from the watch glass and blotted with filter paper to remove the water present on their surface and weighed accurately. The experiment was performed for 5 h. The swelling index was calculated using the following formula (23):

Radial and axial swelling of the tablet. The initial diameter and height of the tablet were measured, and the tablet was stored in distilled water. The increase in diameter and height were measured at selected time intervals up to 5 h. The equilibrium degree of swelling (Q) was calculated from the radial and axial swelling ratio using the following equation:




in which Vt and Vo are the tablet volumes, Rt and Ro are the radii, and It and Io are the heights at time t and zero, respectively (24).

Dissolution-rate study. In vitro drug-dissolution studies were conducted using the USP Type II apparatus (Model TDL-08, Electrolab India, Mumbai) at 50 rpm in distilled water at 37 0.5 C. At specified intervals, 5-mL samples were withdrawn and replaced with fresh medium to keep a constant volume. After appropriate dilution, the sample solutions were analyzed using a UV-visible spectrophotometer (Shimadzu, Kyoto, Japan, Shimadzu-1700) at 276 nm.The amount of drug released was determined by reference to a calibration curve constructed in the three sets of same dissolution media. The mean of the three determinations was used for the data analysis (25).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
28%
Oversee medical treatment of patients in the US.
12%
Provide treatment for patients globally.
9%
All of the above.
45%
No government involvement in patient treatment or drug development.
7%
Jim Miller Outsourcing Outlook Jim MillerCMO Industry Thins Out
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerFluorination Remains Key Challenge in API Synthesis
Marilyn E. Morris Guest EditorialMarilyn E. MorrisBolstering Graduate Education and Research Programs
Jill Wechsler Regulatory Watch Jill Wechsler Biopharma Manufacturers Respond to Ebola Crisis
Sean Milmo European Regulatory WatchSean MilmoHarmonizing Marketing Approval of Generic Drugs in Europe
Seven Steps to Solving Tabletting and Tooling ProblemsStep 1: Clean
Legislators Urge Added Incentives for Ebola Drug Development
FDA Reorganization to Promote Drug Quality
FDA Readies Quality Metrics Measures
New FDA Team to Spur Modern Drug Manufacturing
Source: Pharmaceutical Technology,
Click here