Evaluating Mucilage from Aloe Barbadensis Miller as a Pharmaceutical Excipient for Sustained-Release Matrix Tablets - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Evaluating Mucilage from Aloe Barbadensis Miller as a Pharmaceutical Excipient for Sustained-Release Matrix Tablets
Natural gums and mucilage have been widely explored as pharmaceutical excipients. The goal of this study was to extract mucilage from the leaves of Aloe barbadensis Miller and to study its functionality as an excipient in pharmaceutical sustained-release tablet formulations.


Pharmaceutical Technology


4. G.M. Khan and Z. Jiabi, "Formulation and In-vitro Evaluation of Ibuprofen-carbopol 974P-NF Controlled Release Matrix Tablets III: Influence of Co-Excipients on Release Rate of the Drug." J. Control Release 54 (2), 185–190 (1998).

5. L. Genc, H. Bilac, and E. Guler, "Studies on Controlled Release Dimenhydrinate from Matrix Tablet Formulations," Pharm. Acta Helv. 74 (1), 43–49 (1999).

6. G.T. Kulkarni et al., "Evaluation of Binding Properties of Plantago ovata and Trigonella foenum graecum Mucilage," Indian Drugs 39 (8), 422–425 (2002).

7. B. Anroop et al., "Studies on Ocimum gratissimum Seed Mucilage: Evaluation of Suspending Properties," Indian J. Pharm. Sci. 67 (2), 206–209 (2005).

8. P.D. Bharadia et al., "A Preliminary Investigation on Sesbania Gum as a Pharmaceutical Excipient," Int. J. Pharm. Excipient 1 (4), 102–105 (2004).

9. H. Pawar, and P.M. D'Mello, "Isolation of Seed Gum from Cassia tora and Preliminary Studies of its Application as a Binder for Tablets," Indian Drugs 41 (8), 465–468 (2004).

10. K. Gowthamarajan et al., "Evaluation of Borassus flabellifer Mucilage as Gelling Agent," Indian Drugs 40 (11), 640–644 (2003).

11. C. Evans, Trease & Evans—Pharmacognosy (Elsevier Ltd., New York 15th ed., 2002), pp. 240–244.

12. J. Anjaria, M. Parabia, and S. Dwivedi, Ethnovet Heritage: Indian Ethnoveterinary Medicine an Overview. (Pathik Enterprise, Ahmedabad, India, 1st ed., 2002), p. 194.

13. Goodman's and Gilman's the Pharmacological Basis of Therapeutics, J.G. Hardman, L.E. Limbird, Eds. (McGraw Hill, New York, 9th ed., 1995).

14. P. D. Fowler et al., "Plasma and Synovial Fluid Concentration of Diclofenac Sodium and its Major Hydroxylated Metabolites during Long-term Treatment of Rheumatoid Arthritis," Eur. J. Clin. Pharmacology 25 (3), 389–394 (1983).

15. J.V. Willis, M.J. Kendall, and D.B. Jack, "The Influence of Food on the Absorption of Diclofenac after Single and Multiple Oral Doses," Eur. J. Clin. Pharmacology 19 (1), 33–37 (1981).

16. S.K. Baveja, K.V. Rao, and J. Arora, "Examination of Natural Gums and Mucilages as Sustaining Agents in Tablet Dosage Forms," Indian J. Pharm. Sci. 50 (2), 89–92 (1988).

17. Ministry of Health and Family Welfare, Government of India, Indian Pharmacopoeia (The Controller of Publications, New Delhi, 4th ed., 1996), p. A-89.

18. F.E. Bowen and W.A. Vadino, "A Simple Method for Differentiating Starches," Drug Dev. Ind. Pharm. 10, 505–511 (1984).

19. P. J. Sink, Martin's Physical Pharmacy and Pharmaceutical Science (B. I. Publications Pvt. Ltd., New Delhi, 5th ed., 2006), pp. 553–556.


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
70%
Breakthrough designations
4%
Protecting the supply chain
17%
Expedited reviews of drug submissions
2%
More stakeholder involvement
7%
View Results
Eric Langerr Outsourcing Outlook Eric LangerRelationship-building at Top of Mind for Clients
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerRisk Reduction Top Driver for Biopharmaceutical Raw Material Development
Jill Wechsler Regulatory Watch Jill Wechsler Changes and Challenges for Generic Drugs
Faiz Kermaini Industry Insider Faiz KermainiNo Signs of a Slowdown in Mergers
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Ebola Outbreak Raises Ethical Issues
Better Comms Means a Fitter Future for Pharma, Part 2: Realizing the Benefits of Unified Communications
Better Comms Means a Fitter Future for Pharma, Part 1: Challenges and Changes
Sandoz Wins Biosimilar Filing Race
Source: Pharmaceutical Technology,
Click here