What's Next In: Ingredients - Pharmaceutical Technology

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PharmTech Europe

What's Next In: Ingredients

Pharmaceutical Technology

5. S.S. Zhu et al., "Chiral Mo-Binol Complexes: Activity, Synthesis, and Structure. Efficient Enantioselective Six-Membered Ring Synthesis through Catalytic Metathesis," J. Am. Chem. Soc. 121 (36), 8251-8259 (1999).

6. R.R. Schrock and A.H. Hoveyda, "Molybdenum and Tungsten Imido Alkylidene Complexes as Efficient Olefin-Metathesis Catalysts," Angew. Chem., Int. Ed. 42 (38), 4592-4633 (2003).

7. A.H. Hoveyda and R.R. Schrock, "Catalytic Asymmetric Olefin Metathesis," Chem. Eur. J. 7 (5 ), 945-950 (2001).

8. T.J. Seiders, D.W. Ward, and R.H. Grubbs, "Enantioselective Ruthenium-Catalyzed Ring-Closing Metathesis," Org. Lett. 3 (20) 3225-3228 (2001).

9. J.J. Van Veldhuizen. "A Recyclable Chiral Ru Catalyst for Enantioselective Olefin Metathesis. Efficient Catalytic Asymmetric Ring-Opening/Cross Metathesis in Air," J. Am. Chem. Soc. 124 (18), 4954-4955 (2002).

10. J.J. Van Veldhuizen et al., "Chiral Ru-Based Complexes for Asymmetric Olefin Metathesis: Enhancement of Catalyst Activity through Steric and Electronic Modification," J. Am. Chem. Soc. 125 (41), 12502-12508 (2003).

11. D.G. Gillingham et al., "Efficient Enantioselective Synthesis of Functionalized Tetrahydropyrans by Ru-Catalyzed Asymmetric Ring-Opening Metathesis/Cross-Metathesis (AROM/CM)," J. Am. Chem. Soc. 126 (6), 12288-12290 (2004).

12. T.W. Funk, J.M. Berlin, and R.H. Grubbs, "A Highly Active Palladium Catalyst for Intermolecular Hydroamination. Factors that Control Reactivity and Additions of Functionalized Anilines to Dienes and Vinylarenes," J. Am. Chem. Soc. 128 (6), 1840-1846 (2006).

Industry experts give their predictions for the next 30 years. Read Editor-in-Chief Michelle Hoffman's introduction here. See what's next in:

Strategy and Regulation
Solid-Dosage Formulation
Drug Delivery
Analytical Testing
Information Technology


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FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
View Results
Eric Langerr Outsourcing Outlook Eric LangerTargeting Different Off-Shore Destinations
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAsymmetric Synthesis Continues to Advance
Jill Wechsler Regulatory Watch Jill Wechsler Data Integrity Key to GMP Compliance
Sean Milmo European Regulatory WatchSean MilmoExtending the Scope of Pharmacovigilance Comes at a Price
From Generics to Supergenerics
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Ebola Outbreak Raises Ethical Issues
Better Comms Means a Fitter Future for Pharma, Part 2: Realizing the Benefits of Unified Communications
Better Comms Means a Fitter Future for Pharma, Part 1: Challenges and Changes
Source: Pharmaceutical Technology,
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