Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs - Pharmaceutical Technology

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Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs
The authors propose extending initial solvent screening for a single-solvent system to the cocktail solvent screening of binary and ternary solvent mixtures.


Pharmaceutical Technology
Volume 32, Issue 1

26. E.B. Hershberg and J.E. Christensen, "Manufacture of Soluble Sulfathiazole," US Patent 4070356, (1978).

27. A. Burger and R.D. Dialer, "Neue Untersuchungsergebnisse zur Polymorphic von Sulfathiazol," Pharm. Acta Helv. 58 (3), 72–78 (1983).

28. T.L. Threlfall, "Analysis of Organic Polymorphs: A Review," Analyst 120 (10), 2435–2460 (1995).

29. D. Giron, "Thermal Analysis and Calorimetric Methods in the Characterization of Polymorphs and Solvates," Therm. Acta 248, 1–59 (1995).


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