Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs - Pharmaceutical Technology

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Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs
The authors propose extending initial solvent screening for a single-solvent system to the cocktail solvent screening of binary and ternary solvent mixtures.


Pharmaceutical Technology
Volume 32, Issue 1

Acknowledgements


Figure 11
This work was supported by a grant from the National Science Council of Taiwan (NSC 93-2113-M-008-012-MY2). Suggestions from Ms. Jui-Mei Huang of the National Central University Precision Instrument Center regarding DSC and TGA are gratefully acknowledged.

Tu Lee is an assistant professor and Shi Ting Hung was a graduate student in the Department of Chemical and Materials Engineering and the Institute of Materials Science and Engineering, National Central University, 300 Jhong-Da Rd., Jhong-Li City 320, Taiwan, China, tel. 1886 3 422 7151 ext. 34204, fax 1886 3 425 2296,

*To whom all correspondence should be addressed.

Submitted: Mar. 26, 2007. Accepted: Apr. 27, 2007.

References

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2. J. W. Schroer and K.M. Ng, "Process Paths of Kinetically Controlled Crystallization: Enantiomers and Polymorphs," Ind. Eng. Chem. Res. 42 (10), 2230–2244 (2003).

3. W. Beckmann, "Seeding the Desired Polymorph: Background, Possibilities, Limitations, and Case Studies," Org. Proc. Res. Dev. 4 (5), 372–383 (2000).

4. R. A. Granberg and .C. Rasmuson, "Solubility of Paracetamol in Pure Solvents," J. Chem. Eng. Data 44 (6), 1391–1395 (1999).

5. R. A. Granberg and .C. Rasmuson, "Solubility of Paracetamol in Binary and Ternary Mixtures of Water + Acetone + Toluene," J. Chem. Eng. Data 45 (3), 478–483 (2000).

6. D.J.C. Constable, C. Jimenez-Gonzalez, and R.K. Henderson, "Perspective on Solvent Use in the Pharmaceutical Industry," Org. Proc. Res. Dev. 11 (1), 133–137 (2007).

7. J.W. Mullin, Crystallization, (Butterworth Heinemann, Boston, MA, 3rd ed., 1997), pp. 90–92.

8. J. Breu et al., "Nucleation-Controlled Crystallization of a New, Spontaneously Resolved Solvate of [Ru(bpy)3](PF6)2 and its Desolvation Reaction," Chem. Eur. J. 8 (19), 4454–4460 (2002).

9. N. Blagden et al., "Crystal Chemistry and Solvent Effects in Polymorphic Systems Sulfathiazole," J. Chem. Soc. Faraday Trans. 94 (8), 1035–1044 (1998).

10. A. Kordikowski, T. Shekunov, and P. York, "Polymorph Control of Sulfathaizole in Supercritical CO2," Pharm. Res. 18 (5), 682–688 (2001).


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