Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs
The authors propose extending initial solvent screening for a single-solvent system to the cocktail solvent screening of binary and ternary solvent mixtures.

Pharmaceutical Technology
Volume 32, Issue 1


Figure 11
This work was supported by a grant from the National Science Council of Taiwan (NSC 93-2113-M-008-012-MY2). Suggestions from Ms. Jui-Mei Huang of the National Central University Precision Instrument Center regarding DSC and TGA are gratefully acknowledged.

Tu Lee is an assistant professor and Shi Ting Hung was a graduate student in the Department of Chemical and Materials Engineering and the Institute of Materials Science and Engineering, National Central University, 300 Jhong-Da Rd., Jhong-Li City 320, Taiwan, China, tel. 1886 3 422 7151 ext. 34204, fax 1886 3 425 2296,

*To whom all correspondence should be addressed.

Submitted: Mar. 26, 2007. Accepted: Apr. 27, 2007.


1. C. Sanchez, H. Arribart, and M.M. Giraud-Guille, "Biomimetism and Bioinspiration as Tools for the Design of Innovative Materials and Systems," Nature Mater. 4 (4), 277–288 (2005).

2. J. W. Schroer and K.M. Ng, "Process Paths of Kinetically Controlled Crystallization: Enantiomers and Polymorphs," Ind. Eng. Chem. Res. 42 (10), 2230–2244 (2003).

3. W. Beckmann, "Seeding the Desired Polymorph: Background, Possibilities, Limitations, and Case Studies," Org. Proc. Res. Dev. 4 (5), 372–383 (2000).

4. R. A. Granberg and .C. Rasmuson, "Solubility of Paracetamol in Pure Solvents," J. Chem. Eng. Data 44 (6), 1391–1395 (1999).

5. R. A. Granberg and .C. Rasmuson, "Solubility of Paracetamol in Binary and Ternary Mixtures of Water + Acetone + Toluene," J. Chem. Eng. Data 45 (3), 478–483 (2000).

6. D.J.C. Constable, C. Jimenez-Gonzalez, and R.K. Henderson, "Perspective on Solvent Use in the Pharmaceutical Industry," Org. Proc. Res. Dev. 11 (1), 133–137 (2007).

7. J.W. Mullin, Crystallization, (Butterworth Heinemann, Boston, MA, 3rd ed., 1997), pp. 90–92.

8. J. Breu et al., "Nucleation-Controlled Crystallization of a New, Spontaneously Resolved Solvate of [Ru(bpy)3](PF6)2 and its Desolvation Reaction," Chem. Eur. J. 8 (19), 4454–4460 (2002).

9. N. Blagden et al., "Crystal Chemistry and Solvent Effects in Polymorphic Systems Sulfathiazole," J. Chem. Soc. Faraday Trans. 94 (8), 1035–1044 (1998).

10. A. Kordikowski, T. Shekunov, and P. York, "Polymorph Control of Sulfathaizole in Supercritical CO2," Pharm. Res. 18 (5), 682–688 (2001).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
View Results
Eric Langerr Outsourcing Outlook Eric LangerTargeting Different Off-Shore Destinations
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAsymmetric Synthesis Continues to Advance
Jill Wechsler Regulatory Watch Jill Wechsler Data Integrity Key to GMP Compliance
Sean Milmo European Regulatory WatchSean MilmoExtending the Scope of Pharmacovigilance Comes at a Price
From Generics to Supergenerics
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Ebola Outbreak Raises Ethical Issues
Better Comms Means a Fitter Future for Pharma, Part 2: Realizing the Benefits of Unified Communications
Better Comms Means a Fitter Future for Pharma, Part 1: Challenges and Changes
Source: Pharmaceutical Technology,
Click here