Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs
The authors propose extending initial solvent screening for a single-solvent system to the cocktail solvent screening of binary and ternary solvent mixtures.


Pharmaceutical Technology
Volume 32, Issue 1

11. T. Lee and M.S. Lin, "Sublimation Point Depression of Tris(8-hydroxyquinoline) aluminum (III) (Alq3) by Crystal Engineering," Cryst. Growth Des. 7 (9), 1803–1810 (2007).

12. Y. Kawashima, M. Okumura and H. Takenaka, "Spherical Crystallization: Direct Spherical Agglomeration of Salicylic Acid Crystals During Crystallization," Science 216 (4550), 1127–1128 (1982).

13. R.A. Granberg and .C. Rasmuson, "Crystal Growth Rates of Paracetamol in Mixtures of Water + Acetone + Toluene," AIChE Journal 51 (9), 2441–2456 (2005).

14. M.L. Peterson et al., "Iterative High-Throughput Polymorphism Studies on Acetaminophen and an Experimentally Derived Structure for Form III," J. Am. Chem. Soc. 124 (37), 10958–10959 (2002).

15. J.E. Anderson et al., "Determination of the Onset of Crystallization of N1-2-(thiazolyl)sulfanilamide (sulfathiazole) by UV–Vis and Calorimetry Using an Automated Reaction Platform; Subsequent Characterization of Polymorphic Forms Using Dispersive Raman Spectroscopy," Spectrochimica Acta Part A 57 (9), 1793–1808 (2001).

16. S. Khoshkhoo and J. Anwar, "Crystallization of Polymorphs: the Effect of Solvent," J. Phys. D: Appl. Phys. 26 (8B), B90–B93 (1993).

17. J. Anwar, S.E. Tarling, and P. Barnes, "Polymorphism of Sulfathiazole," J. Pharm Sci. 78 (4), 337–342 (1989).

18. D.C. Grove and G. Keenan, "The Dimorphism of Sulfathiazole," J. Am. Chem. Soc. 63 (1), 97–99 (1941).

19. A.L. Bingham et al., "Over One Hundred Solvates of Sulfathiazole," Chem. Commun. (7), 603–604 (2001).

20. E. Tedesco, D. Giron, and S. Pfeffer, "Crystal Structure Elucidation and Morphology Study of Pharmaceuticals in Development," Cryst. Eng. Comm. 4 (67), 393–400 (2002).

21. N. Blagden and R.J. Davey, "Review: Polymorph Selection—Challenges for the Future?" Cryst. Growth Des. 3 (6), 873–885 (2003).

22. D. Winn and M.F. Doherty, "Modeling Crystal Shapes of Organic Materials Grown from Solution," AIChE J. 46 (7), 1348–1367 (2000).

23. S. Byrn, K. Morris, and S. Comella, "Reducing Time to Market with a Science-Based Product," Pharm. Technol. Outsourcing Resources for the Pharmaceutical Industry supplement, 46–56 (2005).

24. T. Lee, C.S. Kuo, and Y.H. Chen, "Solubility, Polymorphism, Crystallinity, and Crystal Acetaminophen and Ibuprofen by Initial Solvent Screening," Pharm. Technol. 30 (10), 72–92 (2006).

25. N.G. Anderson, Practical Process Research and Development , (Academic Press, New York, 2000), pp. 81–111.


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
32%
Breakthrough designations
11%
Protecting the supply chain
37%
Expedited reviews of drug submissions
11%
More stakeholder involvement
11%
View Results
Jim Miller Outsourcing Outlook Jim Miller Health Systems Raise the Bar on Reimbursing New Drugs
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerThe Mainstreaming of Continuous Flow API Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler Industry Seeks Clearer Standards for Track and Trace
Siegfried Schmitt Ask the Expert Siegfried SchmittData Integrity
Sandoz Wins Biosimilar Filing Race
NIH Translational Research Partnership Yields Promising Therapy
Clusters set to benefit from improved funding climate but IP rights are even more critical
Supplier Audit Program Marks Progress
FDA, Drug Companies Struggle with Compassionate Use Requests
Source: Pharmaceutical Technology,
Click here