Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs - Pharmaceutical Technology

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Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs
The authors propose extending initial solvent screening for a single-solvent system to the cocktail solvent screening of binary and ternary solvent mixtures.


Pharmaceutical Technology
Volume 32, Issue 1

11. T. Lee and M.S. Lin, "Sublimation Point Depression of Tris(8-hydroxyquinoline) aluminum (III) (Alq3) by Crystal Engineering," Cryst. Growth Des. 7 (9), 1803–1810 (2007).

12. Y. Kawashima, M. Okumura and H. Takenaka, "Spherical Crystallization: Direct Spherical Agglomeration of Salicylic Acid Crystals During Crystallization," Science 216 (4550), 1127–1128 (1982).

13. R.A. Granberg and .C. Rasmuson, "Crystal Growth Rates of Paracetamol in Mixtures of Water + Acetone + Toluene," AIChE Journal 51 (9), 2441–2456 (2005).

14. M.L. Peterson et al., "Iterative High-Throughput Polymorphism Studies on Acetaminophen and an Experimentally Derived Structure for Form III," J. Am. Chem. Soc. 124 (37), 10958–10959 (2002).

15. J.E. Anderson et al., "Determination of the Onset of Crystallization of N1-2-(thiazolyl)sulfanilamide (sulfathiazole) by UV–Vis and Calorimetry Using an Automated Reaction Platform; Subsequent Characterization of Polymorphic Forms Using Dispersive Raman Spectroscopy," Spectrochimica Acta Part A 57 (9), 1793–1808 (2001).

16. S. Khoshkhoo and J. Anwar, "Crystallization of Polymorphs: the Effect of Solvent," J. Phys. D: Appl. Phys. 26 (8B), B90–B93 (1993).

17. J. Anwar, S.E. Tarling, and P. Barnes, "Polymorphism of Sulfathiazole," J. Pharm Sci. 78 (4), 337–342 (1989).

18. D.C. Grove and G. Keenan, "The Dimorphism of Sulfathiazole," J. Am. Chem. Soc. 63 (1), 97–99 (1941).

19. A.L. Bingham et al., "Over One Hundred Solvates of Sulfathiazole," Chem. Commun. (7), 603–604 (2001).

20. E. Tedesco, D. Giron, and S. Pfeffer, "Crystal Structure Elucidation and Morphology Study of Pharmaceuticals in Development," Cryst. Eng. Comm. 4 (67), 393–400 (2002).

21. N. Blagden and R.J. Davey, "Review: Polymorph Selection—Challenges for the Future?" Cryst. Growth Des. 3 (6), 873–885 (2003).

22. D. Winn and M.F. Doherty, "Modeling Crystal Shapes of Organic Materials Grown from Solution," AIChE J. 46 (7), 1348–1367 (2000).

23. S. Byrn, K. Morris, and S. Comella, "Reducing Time to Market with a Science-Based Product," Pharm. Technol. Outsourcing Resources for the Pharmaceutical Industry supplement, 46–56 (2005).

24. T. Lee, C.S. Kuo, and Y.H. Chen, "Solubility, Polymorphism, Crystallinity, and Crystal Acetaminophen and Ibuprofen by Initial Solvent Screening," Pharm. Technol. 30 (10), 72–92 (2006).

25. N.G. Anderson, Practical Process Research and Development , (Academic Press, New York, 2000), pp. 81–111.


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