Raw-Material Authentication Using a Handheld Raman Spectrometer - Pharmaceutical Technology

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Raw-Material Authentication Using a Handheld Raman Spectrometer
Using a handheld Raman spectrometer, the authors developed methods for 28 commonly used excipients and active ingredients.

Pharmaceutical Technology
Volume 3, Issue 32

5. J.A. Ryan et al., "Rapid Verification of Identity and Content of Drug Formulations Using Mid-Infrared Spectroscopy," J. Pharm. Biomed. Anal. 9 (4), 303–310 (1991).

6. For example, United States Pharmacopeia-National Formulary and European Pharmacopeia.

7. T. Vankeirsbilck et al., "Applications of Raman Spectroscopy in Pharmaceutical Analysis," TrAC 21 (12), 869–877 (2002).

8. R.L. McCreery et al., "Noninvasive Identification of Materials Inside USP Vials with Raman Spectroscopy and a Raman Spectral Library," J. Pharm. Sci. 87 (1), 1–8 (1998).

9. R. Cantu et al., "A Simple Approach for Developing, Validating, and Transferring an Identification Method for Multidose Pharmaceutical Products using FT-Raman Spectroscopy," Am. Pharm. Review 10 (2), pp. 96–103, 111 (Jan.–Feb. 2007).

10. D.A.C. Compton and S.V. Compton "Examination of Packaged Consumer Goods by Using FT-Raman Spectrometry," Applied Spec. 45 (10), 1587–1589 (1991).

11. S.G.Skoulika and C.A.Geurgio, "Rapid, Noninvasive Quantitative Determination of Acyclovir in Pharmaceutical Solid Dosage Forms Through their Poly(vinyl chloride) Blister Package by Solid-State Fourier Transform Raman Spectroscopy," Applied Spec. 57 (4), 407–412 (2003).

12. R.L. McCreery, "Introduction and Scope," in Raman Spectroscopy for Chemical Analysis (John Wiley & Sons, New York, United States, 2000), pp. 1–14.

13. European Medicines Agency (EMEA), Note for Guidance on the Use of Near Infrared Spectroscopy by the Pharmaceutical Industry and the Data Requirements for New Submissions and Variations (London, UK, 2003).

14. C.T. John and N.C. Pixley "Methodology for NIR Identification of Pharmaceutical Finished Products with Emphasis on Negative Controls and Data Driven Threshold Value Selection," Am. Pharm. Review, 10 (2), 120–124 (Jan–Feb 2007).

15. FDA, Center for Drug Evaluation and Research, Guidance for Industry: Testing of Glycerin for Diethylene Glycol (Rockville, MD, 2007).


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