Raw-Material Authentication Using a Handheld Raman Spectrometer - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Raw-Material Authentication Using a Handheld Raman Spectrometer
Using a handheld Raman spectrometer, the authors developed methods for 28 commonly used excipients and active ingredients.


Pharmaceutical Technology
Volume 3, Issue 32

5. J.A. Ryan et al., "Rapid Verification of Identity and Content of Drug Formulations Using Mid-Infrared Spectroscopy," J. Pharm. Biomed. Anal. 9 (4), 303–310 (1991).

6. For example, United States Pharmacopeia-National Formulary and European Pharmacopeia.

7. T. Vankeirsbilck et al., "Applications of Raman Spectroscopy in Pharmaceutical Analysis," TrAC 21 (12), 869–877 (2002).

8. R.L. McCreery et al., "Noninvasive Identification of Materials Inside USP Vials with Raman Spectroscopy and a Raman Spectral Library," J. Pharm. Sci. 87 (1), 1–8 (1998).

9. R. Cantu et al., "A Simple Approach for Developing, Validating, and Transferring an Identification Method for Multidose Pharmaceutical Products using FT-Raman Spectroscopy," Am. Pharm. Review 10 (2), pp. 96–103, 111 (Jan.–Feb. 2007).

10. D.A.C. Compton and S.V. Compton "Examination of Packaged Consumer Goods by Using FT-Raman Spectrometry," Applied Spec. 45 (10), 1587–1589 (1991).

11. S.G.Skoulika and C.A.Geurgio, "Rapid, Noninvasive Quantitative Determination of Acyclovir in Pharmaceutical Solid Dosage Forms Through their Poly(vinyl chloride) Blister Package by Solid-State Fourier Transform Raman Spectroscopy," Applied Spec. 57 (4), 407–412 (2003).

12. R.L. McCreery, "Introduction and Scope," in Raman Spectroscopy for Chemical Analysis (John Wiley & Sons, New York, United States, 2000), pp. 1–14.

13. European Medicines Agency (EMEA), Note for Guidance on the Use of Near Infrared Spectroscopy by the Pharmaceutical Industry and the Data Requirements for New Submissions and Variations (London, UK, 2003).

14. C.T. John and N.C. Pixley "Methodology for NIR Identification of Pharmaceutical Finished Products with Emphasis on Negative Controls and Data Driven Threshold Value Selection," Am. Pharm. Review, 10 (2), 120–124 (Jan–Feb 2007).

15. FDA, Center for Drug Evaluation and Research, Guidance for Industry: Testing of Glycerin for Diethylene Glycol (Rockville, MD, 2007).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
23%
Oversee medical treatment of patients in the US.
14%
Provide treatment for patients globally.
7%
All of the above.
47%
No government involvement in patient treatment or drug development.
9%
Jim Miller Outsourcing Outlook Jim MillerOutside Looking In
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAdvances in Large-Scale Heterocyclic Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler New Era for Generic Drugs
Sean Milmo European Regulatory WatchSean MilmoTackling Drug Shortages
New Congress to Tackle Health Reform, Biomedical Innovation, Tax Policy
Combination Products Challenge Biopharma Manufacturers
Seven Steps to Solving Tabletting and Tooling ProblemsStep 1: Clean
Legislators Urge Added Incentives for Ebola Drug Development
FDA Reorganization to Promote Drug Quality
Source: Pharmaceutical Technology,
Click here