Polypeptide Multilayer Nanofilms in Drug Delivery - Pharmaceutical Technology

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Polypeptide Multilayer Nanofilms in Drug Delivery
Investigators are exploiting the tremendous structural diversity of polypeptides and their biophysical properties to develop novel drug carriers. Peptide-based materials hold out much promise for tailor-made targeting, penetration, and release of contents in a host of biological microenvironments.

Pharmaceutical Technology

In conclusion, substantial progress has been made in the development of the PMN platform technology in the past few years. From multiple angles the prospects for commercializing the technology look good. The technology is promising for biomaterials development, and it has good potential to influence development of a variety of approaches to drug delivery. The technology could also be useful for development of multifunctional biomaterials. For instance, a variety of bioactive peptides could be used simultaneously to functionalize a PMN for different purposes, or various drugs could be encapsulated simultaneously for co-delivery. It is possible that other basic themes for technology development have yet to be identified. It is certain in any case that many variations on the known themes wait to be explored.

Donald T. Haynie, PhD , is vice-president of research and chief scientific officer at Artificial Cell Technologies, Inc., 5 Science Park at Yale, New Haven, CT 06511, tel. 1 203.772.3430,


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