Dimethyl Sulfoxide USP, PhEur in Approved Pharmaceutical Products and Medical Devices - Pharmaceutical Technology

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Dimethyl Sulfoxide USP, PhEur in Approved Pharmaceutical Products and Medical Devices
The authors survey the approved applications of dimethyl sulfoxide USP, PhEur across the healthcare industry and consider the suitability of DMSO from a regulatory and formulation compatibility standpoint.


Pharmaceutical Technology


22. P.W. Davis "An Incipient 'Wonder Drug' Movement: DMSO and the Food and Drug Administration," Social Problems 32 (32), 197–212 (1984).

23. L. Murdoch "Dimethyl Sulfoxide—An Overview," Canadian Journal of Hospital Pharmacy, 35 (3), 79–85 (1982).

24. A.M Kligman, "Topical Pharmacology and Toxicology of Dimethyl Sulfoxide (DMSO) Part 1," J. Amer. Med. Assoc. 193, 140–148 (1965)

25. A.M Kligman "Topical Pharmacology and Toxicology of Dimethyl Sulfoxide (DMSO) Part 2," J. Amer. Med. Assoc. 193, 151–156 (1965)

26. R.D. Brobyn, "The Human Toxicology of Dimethyl Sulfoxide," J. Amer. Med. Assoc. 243, 497–506 (1975).

27. "The Riddle of DMSO," Narr. Mike Wallace, Prod. Marion Goldin CBS Television Network, March 23, 1980.

28. M.D. Anderson Cancer Center "Herbal/Plant Therapies: DMSO (Dimethyl Sulfoxide)" http://www.mdanderson.org/departments/cimer/display.cfm?id=8e9bcb72-f0a0-11d4-810300508b603a14&method=displayfull&pn=6eb86a59-ebd9-11d4-810100508b603a14 (Sept. 2007), accessed Mar. 14, 2008.

29. B.H Ali, "Dimethyl Sulfoxide: Recent Pharmacological and Toxicological Research," Vet. Human Toxicol. 43 (4) 228–231 (2001).

30. US EPA, "High Production Volume Challenge: Robust Summaries and Test Plans: Dimethyl Sulfoxide" http://www.epa.gov/chemrtk/pubssummaries/dimthslf/c14721tc.htm (Oct. 16, 2007).

31. T.J. Franz, P.A. Lehman, and M.K. Kagy, "Dimethylsulfoxide," in Percutaneous Penetration Enhancers, E.W. Smith and H.I. Maibach, Eds. (CRC Press, Boca Raton, FL, 1st ed, 1995), pp. 116–127.

32. C. Ursin et al., "Permeability of Commercial Solvents Through Living Human Skin," Am. Ind. Hyg. Assoc. J. 56, 651–660 (1995).

33. Chemical Effect Information Center, Problem Definition Study of Dimethyl Sulfoxide (DMSO) and Interactive Health Effects with Other Chemicals, Final Report (Oak Ridge National Laboratory, Oak Ridge, TN, 1984), p. 53.


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