Unfolding Catalytic Routes to APIs - Pharmaceutical Technology

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Unfolding Catalytic Routes to APIs
Chemocatalytic and biocatalytic routes show promise for more efficient syntheses of select active ingredients.

Pharmaceutical Technology


1. M.J. Krische, "Formation of C–C Bonds via Catalytic Hydrogenation," presented at Chiral USA (Philadelphia, PA, July 2007).

2. "The Presidential Green Chemistry Challenge Awards Program: Summary of 2007 Award Entries and Recipients," Environmental Protection Agency (Washington, DC, 2007).

3. M.J. Krische et al., "Diastereo- and Enantioselective Hydrogenative Aldol Coupling of Vinyl Ketones: Design of Effective Monodentate Taddol-Like Phosphonite Ligands," J. Am. Chem. Soc. 130 (9), 2746–2747 (2008).

4. M.Y. Ngai, A. Barchuk, and M.J. Krische, "Iridium-Catalyzed C–C Bond Forming Hydrogenation: Direct Regioselective Reductive Coupling of Alkyl-Substituted Alkynes to Activated Ketones," J. Am. Chem. Soc. 129 (2), 280–281 (2007).

5. M.J. Krische, M.Y. Ngai, and A. Barchuk, "Enantioselecetive Iridium Catalyzed Imine Vinylation: Optically Enriched Allylic Amines via Alkyne-Imine Reductive Coupling Mediated by Hydrogen," J. Am. Chem. Soc. 129 (42), 12644–12645 (2007).

6. J.R. Kong and M.J. Krische, "Catalytic Carbonyl Z-Dienylation via Multicomponent Reductive Coupling of Acetylene to Aldehydes and α-Ketoesters Mediated by Hydrogen: Carbonyl Insertion into Cationic Rhodacyclopentadienes," J. Am. Chem. Soc. 128 (50), 16040–16041 (2006).

7. T. Johannes, R. Woodyer, and H. Zhao. "Efficient Regeneration of NADPH Using an Engineered Phosphite Dehydrogenase," Biotechnology and Bioengineering, 96 (1), 18–26 (2007).


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