Unfolding Catalytic Routes to APIs - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Unfolding Catalytic Routes to APIs
Chemocatalytic and biocatalytic routes show promise for more efficient syntheses of select active ingredients.


Pharmaceutical Technology


References

1. M.J. Krische, "Formation of C–C Bonds via Catalytic Hydrogenation," presented at Chiral USA (Philadelphia, PA, July 2007).

2. "The Presidential Green Chemistry Challenge Awards Program: Summary of 2007 Award Entries and Recipients," Environmental Protection Agency (Washington, DC, 2007).

3. M.J. Krische et al., "Diastereo- and Enantioselective Hydrogenative Aldol Coupling of Vinyl Ketones: Design of Effective Monodentate Taddol-Like Phosphonite Ligands," J. Am. Chem. Soc. 130 (9), 2746–2747 (2008).

4. M.Y. Ngai, A. Barchuk, and M.J. Krische, "Iridium-Catalyzed C–C Bond Forming Hydrogenation: Direct Regioselective Reductive Coupling of Alkyl-Substituted Alkynes to Activated Ketones," J. Am. Chem. Soc. 129 (2), 280–281 (2007).

5. M.J. Krische, M.Y. Ngai, and A. Barchuk, "Enantioselecetive Iridium Catalyzed Imine Vinylation: Optically Enriched Allylic Amines via Alkyne-Imine Reductive Coupling Mediated by Hydrogen," J. Am. Chem. Soc. 129 (42), 12644–12645 (2007).

6. J.R. Kong and M.J. Krische, "Catalytic Carbonyl Z-Dienylation via Multicomponent Reductive Coupling of Acetylene to Aldehydes and α-Ketoesters Mediated by Hydrogen: Carbonyl Insertion into Cationic Rhodacyclopentadienes," J. Am. Chem. Soc. 128 (50), 16040–16041 (2006).

7. T. Johannes, R. Woodyer, and H. Zhao. "Efficient Regeneration of NADPH Using an Engineered Phosphite Dehydrogenase," Biotechnology and Bioengineering, 96 (1), 18–26 (2007).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
70%
Breakthrough designations
4%
Protecting the supply chain
17%
Expedited reviews of drug submissions
2%
More stakeholder involvement
7%
View Results
Eric Langerr Outsourcing Outlook Eric LangerRelationship-building at Top of Mind for Clients
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerRisk Reduction Top Driver for Biopharmaceutical Raw Material Development
Jill Wechsler Regulatory Watch Jill Wechsler Changes and Challenges for Generic Drugs
Faiz Kermaini Industry Insider Faiz KermainiNo Signs of a Slowdown in Mergers
Ebola Outbreak Raises Ethical Issues
Better Comms Means a Fitter Future for Pharma, Part 2: Realizing the Benefits of Unified Communications
Better Comms Means a Fitter Future for Pharma, Part 1: Challenges and Changes
Sandoz Wins Biosimilar Filing Race
NIH Translational Research Partnership Yields Promising Therapy
Source: Pharmaceutical Technology,
Click here