Unfolding Catalytic Routes to APIs - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Unfolding Catalytic Routes to APIs
Chemocatalytic and biocatalytic routes show promise for more efficient syntheses of select active ingredients.

Pharmaceutical Technology


1. M.J. Krische, "Formation of C–C Bonds via Catalytic Hydrogenation," presented at Chiral USA (Philadelphia, PA, July 2007).

2. "The Presidential Green Chemistry Challenge Awards Program: Summary of 2007 Award Entries and Recipients," Environmental Protection Agency (Washington, DC, 2007).

3. M.J. Krische et al., "Diastereo- and Enantioselective Hydrogenative Aldol Coupling of Vinyl Ketones: Design of Effective Monodentate Taddol-Like Phosphonite Ligands," J. Am. Chem. Soc. 130 (9), 2746–2747 (2008).

4. M.Y. Ngai, A. Barchuk, and M.J. Krische, "Iridium-Catalyzed C–C Bond Forming Hydrogenation: Direct Regioselective Reductive Coupling of Alkyl-Substituted Alkynes to Activated Ketones," J. Am. Chem. Soc. 129 (2), 280–281 (2007).

5. M.J. Krische, M.Y. Ngai, and A. Barchuk, "Enantioselecetive Iridium Catalyzed Imine Vinylation: Optically Enriched Allylic Amines via Alkyne-Imine Reductive Coupling Mediated by Hydrogen," J. Am. Chem. Soc. 129 (42), 12644–12645 (2007).

6. J.R. Kong and M.J. Krische, "Catalytic Carbonyl Z-Dienylation via Multicomponent Reductive Coupling of Acetylene to Aldehydes and α-Ketoesters Mediated by Hydrogen: Carbonyl Insertion into Cationic Rhodacyclopentadienes," J. Am. Chem. Soc. 128 (50), 16040–16041 (2006).

7. T. Johannes, R. Woodyer, and H. Zhao. "Efficient Regeneration of NADPH Using an Engineered Phosphite Dehydrogenase," Biotechnology and Bioengineering, 96 (1), 18–26 (2007).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatcchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Obama Administration Halts Attack on Medicare Drug Plans
Source: Pharmaceutical Technology,
Click here