Self-Emulsifying Drug Delivery Systems - Pharmaceutical Technology

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Self-Emulsifying Drug Delivery Systems
This review article explains how self-emulsifying drug delivery systems can increase the solubility and bioavailability of poorly soluble drug.

Pharmaceutical Technology


1. P.P. Bhatt, "Osmotic drug delivery systems for poorly soluble drugs," The Drug Delivery Companies Report Autumn/Winter 2004, 26–29 (PharmaVentures Ltd 2004).

2. D.L. Burcham et al., "Improved oral bioavailability of the hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol solutions," Biopharm. Drug Dispos. 18, 737–742 (1997).

3. T.M. Serajuddin et al., "Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water-soluble drug from solid dispersion," J. Pharm. Sci. 77, 414–417 (1988).

4. R.A. Myers and V.J. Stella, "Systemic bioavailability of penclomedine (NSC-338720) from oil-in-water emulsions administered intraduodenally to rats," 78, 217–226 (1992).

5. R.A. Schwendener and H. Schott, "Lipophilic 1-beta-d -arabinofuranosyl cytosine derivatives in liposomal formulations for oral and parenteral antileukemic therapy in the murine L1210 leukemia model," J. Cancer Res. Clin. Oncol. 122, 723–726 (1996).

6. N.H. Shah et al., "Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs," Int. J. Pharm. 106, 15–23 (1994).

7. R.N. Gursoy and S. Benita, "Self-emulsifying drug delivery systems for improved oral delivery of lipophilic drugs," Biomedicine and Pharmacotherapy 58,173-182 (2004).

8. P.P. Constantinides, "Lipid microemulsion for improving drugs dissolution and oral absorption: physical and biopharmaceutical aspects," Pharm Res. 12, 1561-1572 (1995).

9. S.M. Khoo et al., "Formulation design and bioavailability assessment of lipidic silf-emulsifying formulation of halofanitrine," International Journal of Pharmaceutics 167, 155–164 (1998).

10. N.H. Shah et al., "Self-emulsifying drug delivery systems (SEDDS) with polyglycolized glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs." Int. J. Pharm. 106, 15–23 (1994).

11. J.R. Crison and G.L. Amidon, "Method and formulation for increasing the bioavailability of poorly water-soluble drugs," US Patent No. 5,993,858, issued November 30, 1999.

12. N. Farah, J.P. Laforet and J. Denis, "Self Micro Emulsifying Drug Delivery Systems for improving dissolution of drugs: In vitro evaluations," presented by Gattefosse Patented Technology at the AAPS Annual Meeting in San Diego, November 1994.

13. S. Nazzal and M.A. Khan, "Controlled release of a self-emulsifying formulation from a tablet dosage form: Stability assessment and optimization of some processing parameters," International Journal of Pharmaceutics 315, 110–121 (2006).

14. P.P. Constantinides, "Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects," Pharm. Res. 12, 1561–72 (1995).

15. D.Q.M. Craig et al., "An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy," Int. J. Pharm. 114, 103–110 (1995).

16. N. Gursoy et al., "Excipient effects on in vitro cytotoxicity of a novel paclitaxel selfemulsifying drug delivery system," J. Pharm. Sci. 92, 2420–2427 (2003).

17. T. Gershanik and S. Benita, "Positively-charged self-emulsifying oil formulation for improving oral bioavailability of progesterone," Pharm. Dev. Technol. 1, 147–157 (1996).

18. B.D. Tarr and S.H. Yalkowsky, "Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size," Pharm. Res. 6, 40–43 (1989).

19. S.A. Charman et al., "Self-emulsifying drug delivery system: Formulation and biopharmaceutic evaluation of an investigational lipophilic compound," Pharma. Res. 9, 87 – 93 (1992).

20. R. Holm, I.H.M. Jensen, and J. Sonnergaard, "Optimization of self-microemulsifying drug delivery system using D-optimal design and the desirability function," Drug Development and Industrial Pharmacy 32, 1025 –1032 (2006).

21. H. Shen and M. Zhong, "Preparation and evaluation of self-microemulsifying drug delivery system containing atorvastatin," Journal of Pharmacy and Pharmacology 58, 1183–1191 (2006).

22. P. Patil, P. Joshi, and A. Paradkar, "Effect of formulation variables on preparation and evaluation of gelled self emulsifying drug delivery systems of ketoprofen," AAPS PharmSciTech 5 (3), 1-8 (2004).

23. H.R. Shen and M.K. Zhong, "Preparation and evaluation of selfmicroemulsifying drug delivery systems containing atorvastatin," Journal of Pharmacy and Pharmacology 58, 1183–1191 (2006).


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