Self-Emulsifying Drug Delivery Systems - Pharmaceutical Technology

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Self-Emulsifying Drug Delivery Systems
This review article explains how self-emulsifying drug delivery systems can increase the solubility and bioavailability of poorly soluble drug.


Pharmaceutical Technology


24. Wei Ianlan et al., "Preparation and evaluation of SEDDS and SMEDDS containing Carvedilol," Drug Development and Industrial Pharmacy 31, 785–794 (2005).

25. B.K. Kang et al., "Development of self-microemulsifying drug delivery systems for oral bioavailability enhancement of simvastatin in beagle dogs," International Journal of Pharmaceutics 274, 65–73 (2004).

26. J.Y. Hong et al., "A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption," Journal of Controlled Release 110, 332–338 (2006).

27. G.S. Chaea et al., "Enhancement of the stability of BCNU using self-emulsifying drug delivery systems (SEDDS) and in vitro antitumor activity of self-emulsified BCNU-loaded PLGA wafer," International Journal of Pharmaceutics 301, 6–14 (2005).

28. T.R. Kommuru et al., "Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment," International Journal of Pharmaceutics 212, 233–246 (2001).

29. A.A. Attama et al., "The use of solid self-emulsifying systems in the delivery of diclofenac," International Journal of Pharmaceutics 262, 23–28 (2003).

30. Mauro Serratoni et al., "Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system," European Journal of Pharmaceutics and Biopharmaceutics 65, 94–98 (2007).

31. Mette Grovea et al., "Bioavailability of seocalcitol II: Development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides," European Journal of Pharmaceutical Sciences 28, 233–242 (2006).

32. Wei Wu, Yang Wang and Li Que, "Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system," European Journal of Pharmaceutics and Biopharmaceutics 63, 288–294 (2006).

33. A.A. Date and M.S. Nagarsenker, Design and evaluation of selfnanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil," International Journal of Pharmaceutics 329, 166–172 (2007).

34. E.I. Taha et al., "Preparation and in vitro characterization of selfnanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate," International Journal of Pharmaceutics 285, 109–119 (2004).

Ritesh B. Patel* is a lecturer and Rakesh P. Patel is an assistant professor, both in the Department of Pharmaceutics and Pharmaceutical Technology, S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India,
Madhabhai M. Patel is a professor in the Department of Pharmaceutics, Kalol Pharmacy College, Kalol, Gujarat, India. *To whom all correspondence should be addressed.


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