Highly Efficient Olefin-Metathesis Catalysts - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Highly Efficient Olefin-Metathesis Catalysts
The authors describe the Piers' catalysts and detail latest progress in olefin-metathesis catalyst technology.


Pharmaceutical Technology


7. S.R. Dubberley et al., "Synthesis, Characterization and Olefin Metathesis Studies of a Family of Ruthenium Phosphonium Alkylidene Complexes," Inorg. Chim. Acta. 359 (9), 2658–2664 (2006).

8. P.E. Romero and W.E. Piers, "Direct Observation of a 14-Electron Ruthenacyclobutane Relevant to Olefin Metathesis," J. Am. Chem. Soc. 127 (14), 5032–5033 (2005).

9. C. W. Lee et al., "Impurity Reduction in Olefin Metathesis Reactions," US Patent Application US2005/0203324 A1 (Priority Date Aug. 23, 2004, released Sept. 15, 2005).

10. B.P. Paulson and R.L. Pederson, "Impurity Inhibition in Olefin-Metathesis Reactions," US Patent 6,900,347, issued May 31, 2005.

11. R.L. Pederson and B. P. Paulson, "Impurity Inhibition in Olefin-Metathesis Reactions," WO 02094748, A1 Priority Date May 24, 2001.

12. R.L. Pederson et al., "Applications of Olefin Cross Metathesis to Commercial Products," Adv. Synth. Catal. 344 (6–7), 728–735 (2002).

13. K.C. Nicolaou, A. Ortiz, and R.M. Denton, "Metathesis Reaction in the Synthesis of Complex Molecules," Chem. Today 25 (5), 70–76 (2007).

14. D.J. Wallace et al., "A Double Ring Closing Metathesis Reaction in the Rapid, Enantioselective Synthesis of NK-1 Receptor Antagonists," Org. Lett. 3 (5), 671–674 (2001).

15. R.M. Kanada et al., "Total Synthesis of the Potent Antitumor macrolides Pladienolide B and D," Angew. Chem., Int. Ed. 46 (23), 4350–4355 (2007).

16. P. Schwab, R.H. Grubbs, and J.W. Ziller, "Synthesis and Applications of RuCl2 (=CHR')(PR3)2: The Influence of the Alkylidene Moiety on Metathesis Activity," J. Am. Chem. Soc. 118 (1), 100–110 (1996).

17. M. Scholl, S. Ding, C.W. Lee, and R.H. Grubbs, "Synthesis and Activity of a New Generation of Ruthenium-Based Olefin Metathesis Catalysts Coordinated with 1,3-Dimesityl-4,5-dihydroimidazole-2-ylidene Ligands," Org. Lett. 1 (6), 953–956 (1999).

18. S.B. Garber et al., "Efficient and Recyclable Monomeric and Dendritic Ru-Based Metathesis Catalysts," J. Am. Chem. Soc. 122 (34), 8168–8179 (2000).

19. I.C. Stewart et al., "Highly Efficient Ruthenium Catalysts for the Formation of Tetrasubstituted Olefins via Ring-Closing Metathesis," Org. Lett. 9 (8), 1589–1592 (2007).

20. C.K. Chung and R.H. Grubbs, "Olefin Metathesis Catalyst: Stabilization Effect of Backbone Substitutions of N -Heterocyclic Carbene," Org. Lett. 10 (13), 2693–2692 (2008).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
32%
Breakthrough designations
8%
Protecting the supply chain
40%
Expedited reviews of drug submissions
8%
More stakeholder involvement
12%
View Results
Jim Miller Outsourcing Outlook Jim Miller Health Systems Raise the Bar on Reimbursing New Drugs
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerThe Mainstreaming of Continuous Flow API Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler Industry Seeks Clearer Standards for Track and Trace
Siegfried Schmitt Ask the Expert Siegfried SchmittData Integrity
Sandoz Wins Biosimilar Filing Race
NIH Translational Research Partnership Yields Promising Therapy
Clusters set to benefit from improved funding climate but IP rights are even more critical
Supplier Audit Program Marks Progress
FDA, Drug Companies Struggle with Compassionate Use Requests
Source: Pharmaceutical Technology,
Click here