Highly Efficient Olefin-Metathesis Catalysts - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Highly Efficient Olefin-Metathesis Catalysts
The authors describe the Piers' catalysts and detail latest progress in olefin-metathesis catalyst technology.


Pharmaceutical Technology


21. D.E. White et al., "The Catalytic Asymmetric Total Synthesis of Elatol," J. Am. Chem. Soc. 130 (3), 810–811 (2008).

22. J.A. Enquist, Jr. and B.M. Stoltz "The Total Synthesis of (-)-Cyanthiwigin F by Means of Double Catalytic Enantioselective Alkylation," Nature 453, 1228–1231 (2008).

23. The Cross-metathesis of 5-decene and 1,10-diacetoxy-5-decene with Catalyst 2b is Slightly Slower than that with the 2nd Generation Grubbs Catalyst 2. Materia (Pasadena, CA), unpublished results.

24. Y. Schrodi et al., "Ruthenium Olefin Metathesis Catalysts for the Ethenolysis of Renewable Feedstocks," Clean—Soil, Air, Water, 36 (8) 619-673 (2008), in press.

25. K.A. Burdett et al., "Renewable Monomer Feedstocks via Olefin Metathesis: Fundamental Mechnistic Studies of Methyl Oleate Ethenolysis with the First-generation Grubbs Catalyst," Organometallics 23 (9), 2027–2047 (2004).

26. Corma, S. Iborra and A. Velty, "Chemical Routes for the Transformation of Biomass into chemicals," Chem. Rev. 107 (6), 2411–2502 (2007).

27. G. Chen et al., "Efficient Synthesis of a-C-galactosyl Ceramide Immunostimulants: Use of Ethylene-Promoted Olefin Cross-Metathesis," Org. Lett. 6 (22), 4077–4080 (2004).

28. D.R. Anderson et al., "Kinetic Selectivity of Olefin Metathesis Catalysts Bearing Cyclic (Alkyl)(Amino) Carbenes," Organometallics 27 (4), 563–566 (2008).

29. Materia, "Results: Yield (GC%) = sum of the percentages of metathesis products as determined by gas chromatography using FID detection (Materia, Pasadena, CA, 2008).

30. E.F. van del Eide, P.E. Romero, and W.E. Piers, "Generation and Spectroscopic Characterization of Ruthenacyclobutane and Ruthenium Olefin Carbene Intermediates Relevant to Ring-Closing Metathesis Catalysis," J. Am. Chem. Soc. 130 (13), 4485–4491 (2008).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
70%
Breakthrough designations
4%
Protecting the supply chain
17%
Expedited reviews of drug submissions
2%
More stakeholder involvement
7%
View Results
Eric Langerr Outsourcing Outlook Eric LangerRelationship-building at Top of Mind for Clients
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerRisk Reduction Top Driver for Biopharmaceutical Raw Material Development
Jill Wechsler Regulatory Watch Jill Wechsler Changes and Challenges for Generic Drugs
Faiz Kermaini Industry Insider Faiz KermainiNo Signs of a Slowdown in Mergers
Ebola Outbreak Raises Ethical Issues
Better Comms Means a Fitter Future for Pharma, Part 2: Realizing the Benefits of Unified Communications
Better Comms Means a Fitter Future for Pharma, Part 1: Challenges and Changes
Sandoz Wins Biosimilar Filing Race
NIH Translational Research Partnership Yields Promising Therapy
Source: Pharmaceutical Technology,
Click here