Highly Efficient Olefin-Metathesis Catalysts - Pharmaceutical Technology

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Highly Efficient Olefin-Metathesis Catalysts
The authors describe the Piers' catalysts and detail latest progress in olefin-metathesis catalyst technology.


Pharmaceutical Technology


21. D.E. White et al., "The Catalytic Asymmetric Total Synthesis of Elatol," J. Am. Chem. Soc. 130 (3), 810–811 (2008).

22. J.A. Enquist, Jr. and B.M. Stoltz "The Total Synthesis of (-)-Cyanthiwigin F by Means of Double Catalytic Enantioselective Alkylation," Nature 453, 1228–1231 (2008).

23. The Cross-metathesis of 5-decene and 1,10-diacetoxy-5-decene with Catalyst 2b is Slightly Slower than that with the 2nd Generation Grubbs Catalyst 2. Materia (Pasadena, CA), unpublished results.

24. Y. Schrodi et al., "Ruthenium Olefin Metathesis Catalysts for the Ethenolysis of Renewable Feedstocks," Clean—Soil, Air, Water, 36 (8) 619-673 (2008), in press.

25. K.A. Burdett et al., "Renewable Monomer Feedstocks via Olefin Metathesis: Fundamental Mechnistic Studies of Methyl Oleate Ethenolysis with the First-generation Grubbs Catalyst," Organometallics 23 (9), 2027–2047 (2004).

26. Corma, S. Iborra and A. Velty, "Chemical Routes for the Transformation of Biomass into chemicals," Chem. Rev. 107 (6), 2411–2502 (2007).

27. G. Chen et al., "Efficient Synthesis of a-C-galactosyl Ceramide Immunostimulants: Use of Ethylene-Promoted Olefin Cross-Metathesis," Org. Lett. 6 (22), 4077–4080 (2004).

28. D.R. Anderson et al., "Kinetic Selectivity of Olefin Metathesis Catalysts Bearing Cyclic (Alkyl)(Amino) Carbenes," Organometallics 27 (4), 563–566 (2008).

29. Materia, "Results: Yield (GC%) = sum of the percentages of metathesis products as determined by gas chromatography using FID detection (Materia, Pasadena, CA, 2008).

30. E.F. van del Eide, P.E. Romero, and W.E. Piers, "Generation and Spectroscopic Characterization of Ruthenacyclobutane and Ruthenium Olefin Carbene Intermediates Relevant to Ring-Closing Metathesis Catalysis," J. Am. Chem. Soc. 130 (13), 4485–4491 (2008).


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