Industrial Applications of Whole-Cell Biocatalysis - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Industrial Applications of Whole-Cell Biocatalysis
Recombinant microbial whole-cell biocatalysis is a valuable approach for producing enantiomerically pure interemediates. The authors examine several groups of enzymes using this approach: dehydrogenases, hydantoinases, and acylases.


Pharmaceutical Technology


21. N.O.V. Sonntag, "The Reactions of Aliphatic Acid Chlorides," Chem. Rev. 52 (2), 237–416 (1953).

22. S. Tokuyama, K. Hatano, and T. Takahashi, "Discovery of a Novel Enzyme, N-Acylamino Acid Racemase in an Actinomycete: Screening, Isolation, and Identification," Biosci. Biotech. Biochem. 58 (1), 24–27 (1994).

23. S. Tokuyama and K. Hatano, "Purification and Properties of Thermostable N-Acylamino Acid Racemase from Amycolatopsis sp. TS-1-60," Appl. Microbiol. Biotechnol. 42 (6), 853–859 (1992).

24. S. Tokuyama and K. Hatano, "Cloning, DNA Sequencing and Heterologous Expression of the Gene for Thermostable N-Acylamino Acid Racemase from Amycolatopsis sp. TS-1-60 in Escherichia coli," Appl. Microbiol. Biotechnol. 42 (6), 884–889 (1992).

25. D.R. Palmer, et al., "Unexpected Divergence of Enzyme Function and Sequence: N-Acylamino Acid Racemase Is o-Succinylbenzoate Synthase," Biochemistry 38 (14), 4252–4258 (1999).

26. S. Verseck, A.S. Bommarius, and M.R. Kula, "Screening, Overexpression and Characterization of an N-Acylamino Acid Racemase from Amycolatopsis orientalis subsp. Lurida," Appl. Microbiol. Biotechnol. 55 (3), 354-361 (2001).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
27%
Attracting a skilled workforce
27%
Obtaining/maintaining adequate financing
14%
Regulatory compliance
32%
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Report: Pfizer Makes $101 Billion Offer to AstraZeneca
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Source: Pharmaceutical Technology,
Click here