The Role of Dendrimers in Topical Drug Delivery - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

The Role of Dendrimers in Topical Drug Delivery
This review provides an update of how dendrimer technology is being applied to the development of novel systems for various topical delivery applications.

Pharmaceutical Technology
Volume 32, Issue 11, pp. 88-98


1. J. Corbett et. al., "Nanotechnology: International Developments and Emerging Products." CIRP Annals–Manufac. Tech. 49 (2), 523–545 (2000).

2. P.G. Collins and P. Avouris, "Nanotubes for Electronics," Scientific American 283 (6), 62–69 (2000).

3. L.L. Sohn, "Nanotechnology: A Quantum Leap for Electronics," Nature 394 (7), 131–132 (1998).

4. R. Schueller and P. Romanowski, "Emerging Technologies and the Future of Cosmetic Science," Cosmetics & Toiletries 120 (10), 67–74 (2005).

5. G. Brumfiel, "Consumer Products Leap Aboard the Nano Bandwagon," Nature 440 (7082), 262 (2006).

6. K. Bouchemal et al., "Nano-Emulsion Formulation Using Spontaneous Emulsification: Solvent, Oil and Surfactant Optimization," Int. J. Pharm. 280 (1-2), 241–251 (2004).

7. S.M. Moghimi, A.C. Hunter, and J.C. Murray, "Nanomedicine: Current Status and Future Prospects," FASEB J. Review 19 (3), 311–330 (2005).

8. S. Logothetidis, "Nanotechnology in Medicine: The Medicine of Tomorrow and Nanomedicine," Hippokratia 10 (1), 7–21 (2006).

9. G.L. Coté, "Noninvasive and Minimally Invasive Optical Monitoring Technologies," J. Nutr. 131 (5), 1596–1604S (2001).

10. A. Lymberis and L. Gatzoulis, "Wearable Health Systems: From Smart Technologies to Real Applications," in Conference Proceedings of the Engineering in Medicine and Biology Society, 6789–6792 (2006).

11. T. Tanaka et al. "Nanotechnology for Breast Cancer Therapy," Biomed. Microdevices 7 (2008).

12. H.M. El-Laithy, "Self-Nanoemulsifying Drug Delivery System for Enhanced Bioavailability and Improved Hepatoprotective Activity of Biphenyl Dimethyl Dicarboxylate," Curr. Drug Deliv. 5 (3), 170–176 (2008).

13. L.J. Peek, L. Roberts, and C. Berkland, "Poly(D,L-lactide-co-glycolide) Nanoparticle Agglomerates as Carriers in Dry Powder Aerosol Formulation of Proteins," Langmuir 24 (17), 9775–9783 (2008).

14. R. Kumar, "Nano and Microparticles as Controlled Drug Delivery Devices," J. Pharm. Sci. 3 (2), 234–258 (2000).

15. S. Lu, W. Gao, and H.Y. Gu, "Construction, Application and Biosafety of Silver Nanocrystalline Chitosan Wound Dressing," Burns 34 (5), 623–628 (2008).

16. V. Wagner et al., "The Emerging Nanomedicine Landscape," Nature Biotech 24 (10), 1211–1217 (2006).

17. M.C. Roco, "Nanotechnology: Convergence with Modern Biology and Medicine," Curr. Opin. Biotechnol. 14 (3), 337–346 (2003).

18. Y. Zhang et al., "Recent Development of Polymer Nanofibers for Biomedical and Biotechnological Applications," J. Mater. Sci. Mater. Med. 16 (10), 933–946 (2005).

19. A. Samad, Y. Sultana, and M. Aqil. "Liposomal Drug Delivery Systems: An Update Review," Curr Drug Deliv. 4 (4), 297–305 (2007).

20. S.C. McBain, H.H. Yiu, and J. Dobson, "Magnetic Nanoparticles for Gene and Drug Delivery," Int. J. Nanomedicine 3 (2), 169–180 (2008).

21. X. B. Xiong et al., "Multifunctional Polymeric Micelles for Enhanced Intracellular Delivery of Doxorubicin to Metastatic Cancer Cells," Pharm. Res. 25 (11), 2555–2566 (2008).

22. R. D. Mishra, "Quantum Dots for Tumor-Targeted Drug Delivery and Cell Imaging," Nanomed. 3 (3), 271–274 (2008).

23. Y. Cheng et al., "Pharmaceutical Applications of Dendrimers: Promising Nanocarriers for Drug Delivery," Frontiers in Biosci. 1 (13) 1447–1471 (2008).

24. U. Boasand and P. Heegaard, "Dendrimers in Drug Research" Chem. Soc. Rev. 33 (1), 43–63 (2004).

25. Y. Kim, A.M. Klutz, and K.A. Jacobson, "Systematic Investigation of Polyamidoamine Dendrimers Surface-Modified with Poly(ethylene glycol) for Drug Delivery Applications: Synthesis, Characterization, and Evaluation of Cytotoxicity," Bioconjug. Chem. 9 (8), 1660–1672 (2008).

26. J. J. Khandare et al., "Dendrimer Versus Linear Conjugate: Influence of Polymeric Architecture on the Delivery and Anticancer Effect of Paclitaxel," Bioconjug. Chem. 17 (6), 1464–1472 (2006).

27. E. W. Buhleier, W. Wehner, and F. Vogtle, "'Cascade' and 'Nonskid Chain-like' Synthesis of Molecular Cavity Topologies," Synthesis 55 (2), 155–158 (1978).

28. D.A. Tomalia et al., "A New Class of Polymers: Starburst-Dendritic Macromolecules," Polym. J. 17 (1), 117–132 (1985).

29. C.J. Hawker and J.M. J. Frechet, "Preparation of Polymers with Controlled Molecular Architecture: A New Approach to Dendritic Macromolecules," J. Am. Chem. Soc. 112 (21) 7638–7647 (1990).

30. L.M. Passeno, M.E. Mackay, and G.L. Baker, "Conformational Changes of Linear-Dendrimer Diblock Copolymers in Dilute Solution," Macromol. 39 (2), 740–746 (2006).

31. T.H. Moure et al., "Unique Behavior of Dendritic Macromolecules: Intrinsic Viscosity of Polyether Dendrimers," Macromol. 25 (9), 2401–2406 (1992).

32. M. Liu and J.M. Fréchet, "Designing Dendrimers for Drug Delivery," Pharm. Sci. & Technol. Today 2 (10), 393–401 (1999).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Report: Pfizer Makes $101 Billion Offer to AstraZeneca
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Source: Pharmaceutical Technology,
Click here