Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems
Novel hydrophobic bioadhesive polymers and dosage designs are now available to effectively achieve tailored release kinetics of a broad range of drugs to meet the clinical needs.

Pharmaceutical Technology
Volume 32, Issue 11, pp. 100-121

6. A. Bernkop-Schnurch and G. Walker, "Multifunctional Matrices for Oral Peptide Delivery," Crit. Rev. Drug Carrier Syst. 18, 459–501 (2001).

7. J.C. Richardson et al., "Oesophageal Bioadhesion of Sodium Alginate Suspensions, Particle Swelling and Mucosal Retention," Eur. J. Pharm. Sci. 23, 49–56 (2004).

8. D.S. Jones, A.D. Woolfson, and A.F. Brown, "Viscoelastic Properties of Bioadhesive, Chlorhexidine Containing Semisolids for Topical Application to the Oropharynx," Pharm. Res. 15, 1131–1136 (1998).

9. M.K. Chourasia and S.K. Jain, "Pharmaceutical Approaches to Colon Targeted Delivery Systems," J. Pharm. Pharmacol. 6, 33–66 (2003).

10. A. Nangia, "Bioadhesives for Targeted Oral Drug Delivery," Drug Delivery Report (summer) 46–54 (2006).

11. H.H. Sigurdsson, T. Loftsson, and C. Lehy, "Assessment of Mucoadhesion by a Resonant Mirror Biosensor," Int. J. Pharm. 325, 75–81 (2006).

12. J.D. Smart, "The Basics and Underlying Mechanisms of Mucoadhesion," Adv. Drug Delivery Reviews 57, 1556–1568 (2005).

13. A. Rubinstein and B. Tirosh, "Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for Mucoadhesion," Pharm. Res. 11, 794–799 (1994).

14. M. Säkkinen et al., "Gramma-Scintigraphic Evaluation of the Fate of Microcrystalline Chitosan Granules in Human Stomach," Eur. J. Pharm. Biopharm. I57, 133–143 (2004).

15. M. Säkkinen et al., "Evaluation of Microcrystalline Chitosan for Gastro-Retentive Drug Delivery," Eur. J. Pharm. Sci. 19, 345–353 (2003).

16. N.A. Peppsa and Y. Huang, "Nanoscale Technology through Mucoadhesive Interactions," Adv. Drug Del. Rev. 56, 1675–1678 (2004).

17. S.A. Mortazavi and J.D. Smart, "An In Vitro Method for Assessing the Duration of Mucoadhesion," J. Controlled Release 31, 207–212 (1994).

18. D.E. Chickering and E. Mathiowitz, "Definitions, Mechanism, and Theories of Bioadhesion," in Bioadhesive Drug Delivery System, E. Mathiowitz, D.E. Chickering, C.M. Lehr, Eds. (Marcel Dekker, New York, NY, 1999), pp. 1–10.

19. C.A. Santos et al., "Poly(fumaric-co-sebacic anhydride): A Degradation Study as Evaluated by FTIR, DSC, GPC, and X-ray Diffraction," J. Controlled Release 60, 11–22 (1999).

20. A.A. Mortazavi and H.R. Moghimi, "The Effect of Hydroxyl Containing Tablet Excipients on the Adhesive Duration of Some Mucoadhesive Polymers," DARU 12, 11–17 (2004).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Report: Pfizer Makes $101 Billion Offer to AstraZeneca
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Source: Pharmaceutical Technology,
Click here