Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems - Pharmaceutical Technology

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Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems
Novel hydrophobic bioadhesive polymers and dosage designs are now available to effectively achieve tailored release kinetics of a broad range of drugs to meet the clinical needs.

Pharmaceutical Technology
Volume 32, Issue 11, pp. 100-121

6. A. Bernkop-Schnurch and G. Walker, "Multifunctional Matrices for Oral Peptide Delivery," Crit. Rev. Drug Carrier Syst. 18, 459–501 (2001).

7. J.C. Richardson et al., "Oesophageal Bioadhesion of Sodium Alginate Suspensions, Particle Swelling and Mucosal Retention," Eur. J. Pharm. Sci. 23, 49–56 (2004).

8. D.S. Jones, A.D. Woolfson, and A.F. Brown, "Viscoelastic Properties of Bioadhesive, Chlorhexidine Containing Semisolids for Topical Application to the Oropharynx," Pharm. Res. 15, 1131–1136 (1998).

9. M.K. Chourasia and S.K. Jain, "Pharmaceutical Approaches to Colon Targeted Delivery Systems," J. Pharm. Pharmacol. 6, 33–66 (2003).

10. A. Nangia, "Bioadhesives for Targeted Oral Drug Delivery," Drug Delivery Report (summer) 46–54 (2006).

11. H.H. Sigurdsson, T. Loftsson, and C. Lehy, "Assessment of Mucoadhesion by a Resonant Mirror Biosensor," Int. J. Pharm. 325, 75–81 (2006).

12. J.D. Smart, "The Basics and Underlying Mechanisms of Mucoadhesion," Adv. Drug Delivery Reviews 57, 1556–1568 (2005).

13. A. Rubinstein and B. Tirosh, "Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for Mucoadhesion," Pharm. Res. 11, 794–799 (1994).

14. M. Säkkinen et al., "Gramma-Scintigraphic Evaluation of the Fate of Microcrystalline Chitosan Granules in Human Stomach," Eur. J. Pharm. Biopharm. I57, 133–143 (2004).

15. M. Säkkinen et al., "Evaluation of Microcrystalline Chitosan for Gastro-Retentive Drug Delivery," Eur. J. Pharm. Sci. 19, 345–353 (2003).

16. N.A. Peppsa and Y. Huang, "Nanoscale Technology through Mucoadhesive Interactions," Adv. Drug Del. Rev. 56, 1675–1678 (2004).

17. S.A. Mortazavi and J.D. Smart, "An In Vitro Method for Assessing the Duration of Mucoadhesion," J. Controlled Release 31, 207–212 (1994).

18. D.E. Chickering and E. Mathiowitz, "Definitions, Mechanism, and Theories of Bioadhesion," in Bioadhesive Drug Delivery System, E. Mathiowitz, D.E. Chickering, C.M. Lehr, Eds. (Marcel Dekker, New York, NY, 1999), pp. 1–10.

19. C.A. Santos et al., "Poly(fumaric-co-sebacic anhydride): A Degradation Study as Evaluated by FTIR, DSC, GPC, and X-ray Diffraction," J. Controlled Release 60, 11–22 (1999).

20. A.A. Mortazavi and H.R. Moghimi, "The Effect of Hydroxyl Containing Tablet Excipients on the Adhesive Duration of Some Mucoadhesive Polymers," DARU 12, 11–17 (2004).


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