Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems - Pharmaceutical Technology

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Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems
Novel hydrophobic bioadhesive polymers and dosage designs are now available to effectively achieve tailored release kinetics of a broad range of drugs to meet the clinical needs.


Pharmaceutical Technology
Volume 32, Issue 11, pp. 100-121

6. A. Bernkop-Schnurch and G. Walker, "Multifunctional Matrices for Oral Peptide Delivery," Crit. Rev. Drug Carrier Syst. 18, 459–501 (2001).

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8. D.S. Jones, A.D. Woolfson, and A.F. Brown, "Viscoelastic Properties of Bioadhesive, Chlorhexidine Containing Semisolids for Topical Application to the Oropharynx," Pharm. Res. 15, 1131–1136 (1998).

9. M.K. Chourasia and S.K. Jain, "Pharmaceutical Approaches to Colon Targeted Delivery Systems," J. Pharm. Pharmacol. 6, 33–66 (2003).

10. A. Nangia, "Bioadhesives for Targeted Oral Drug Delivery," Drug Delivery Report (summer) 46–54 (2006).

11. H.H. Sigurdsson, T. Loftsson, and C. Lehy, "Assessment of Mucoadhesion by a Resonant Mirror Biosensor," Int. J. Pharm. 325, 75–81 (2006).

12. J.D. Smart, "The Basics and Underlying Mechanisms of Mucoadhesion," Adv. Drug Delivery Reviews 57, 1556–1568 (2005).

13. A. Rubinstein and B. Tirosh, "Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for Mucoadhesion," Pharm. Res. 11, 794–799 (1994).

14. M. Säkkinen et al., "Gramma-Scintigraphic Evaluation of the Fate of Microcrystalline Chitosan Granules in Human Stomach," Eur. J. Pharm. Biopharm. I57, 133–143 (2004).

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16. N.A. Peppsa and Y. Huang, "Nanoscale Technology through Mucoadhesive Interactions," Adv. Drug Del. Rev. 56, 1675–1678 (2004).

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18. D.E. Chickering and E. Mathiowitz, "Definitions, Mechanism, and Theories of Bioadhesion," in Bioadhesive Drug Delivery System, E. Mathiowitz, D.E. Chickering, C.M. Lehr, Eds. (Marcel Dekker, New York, NY, 1999), pp. 1–10.

19. C.A. Santos et al., "Poly(fumaric-co-sebacic anhydride): A Degradation Study as Evaluated by FTIR, DSC, GPC, and X-ray Diffraction," J. Controlled Release 60, 11–22 (1999).

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