Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems - Pharmaceutical Technology

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Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems
Novel hydrophobic bioadhesive polymers and dosage designs are now available to effectively achieve tailored release kinetics of a broad range of drugs to meet the clinical needs.


Pharmaceutical Technology
Volume 32, Issue 11, pp. 100-121

21. M.J. Tobyn, J.R. Johnson, and P.W. Dettmar, "Factors Affecting In Vitro Gastric Mucoadhesion: Influence of Tablet Excipients, Surfactants and Aalts on the Observed Mucoadhesion of Polymers," Eur. J. Pharm. Biopharm. 43, 65–71 (1997)

22. S. B. Bredenberg et al., "In Vitro and In Vivo E valuation of a New Sublingual Tablet System for Rapid Oromucosal Absorption using Fentanyl Citrate as the Active Substance," Eur. J. Pharm. Sci. 20, 327–334 (2003).

23. D.J. Debrozsi, R.L. Smith, and A.A. Sakr, "Comparative Mucoretention of Sucralfate Suspension in an Everted Rat Esophageal Model," Int. J. Pharm. 189, 81–89 (1999).

24. A.M. Potts et al., "Oesophageal Bandaging: A New Opportunity for Thermosetting Polymers," STP Pharm. Sci. 10, 293–301 (2000).

25. H. Batchelor, "Bioadhesive Dosage Forms for Esophageal Drug Delivery," Pharm. Res. 22, 175–181 (2005).

26. L. Zhang and H.K. Batchelor, "A Bioadhesive Formulation for the Delivery of Antifungal Agents to Oesophagus," J. Pharm. Pharmacol . 56, 44 (2004).

27. H. Nagano et al., "Preparation of Magnetic Granules Containing Bleomycin and Its Evaluation using Model Esophageal Cancer," Int. J. Pharm. 147, 119–125 (1997).

28. J.C. Richardson et al., "Oesophageal Bioadhesion of Sodium Alginate Suspensions 2. Suspension Behavior on Oesophageal Mucosa," Eur. J. Pharm. Sci. 24, 107–114 (2005).

29. S. Collaud et al., "Clinical Evaluation of Bioadhesive Hydrogels for Topical Delivery of Hexylaminolevulinate to Barrett's Esophagus," J. Controlled Release 123, 203–210 (2007).

30. H. Al-Dujaili, A.T. Florence, and E.G. Salole, "The Adhesiveness of Proprietary Tablets and Capsules to Porcine Oesophageal Tissue," Int. J. Pharm. 34, 75–79 (1986).

31. K.M. Tur, H.S. Ch'ng, and S. Baie, "Use of Bioadhesive Polymers to Improve the Bioavailability of Griseofulvin," Int. J. Pharm. 148, 63–71 (1997).

32. D. Harris et al., "GI Transit of Potential Bioadhesive Formulations in Man: A Scintigraphic Study," J. Controlled Release 12, 45–53 (1990).

33. G. Santus et al., "An In Vitro–In Vivo Investigation of Oral Bioadhesive Controlled Release Furosemide Formulations," Eur. J. Pharm. Biopharm. 44, 39–52 (1997).

34. J. Jacob et al., "Prolonged Upper GI Residence Time in Dogs of Bioadhesive-Coated Spheres," in Proceedings of CRS Annual Meeting (2003).

35. P. Moslemy et al., "Pharmacokinetic Studies with a Mucoadhesive Multilayer Extended Release Tablet Formulation of Levodopa-Carbidopa in Fed and Fasted Beagles," CRS International Symposium on Bioactive Materials, Abstract #2502 (2007).


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