Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems
Novel hydrophobic bioadhesive polymers and dosage designs are now available to effectively achieve tailored release kinetics of a broad range of drugs to meet the clinical needs.

Pharmaceutical Technology
Volume 32, Issue 11, pp. 100-121

36. P. Moslemy et al., "Pharmacokinetic Studies with a Mucoadhesive Multilayer Extended Release Tablet Formulation of Levodopa-Carbidopa in Healthy Volunteers" in Proceedings of CRS Annual Meeting, Abstract #2499 (2007).

37. D.K. Haswani et al., "Pharmacokinetic Evaluation of Extended Release and Immediate Release Formulations of Pramipexole," CRS International Symposium on Bioactive Materials, Abstract #2104 (2007).

38. L. Yang, J.S. Chu, and J.A. Fix, "Colon-Specific Drug Delivery: New Approaches and In Vitro–In Vivo Evaluation," Int. J. Pharm. 235, 1–15 (2002).

39. J. Kopecek et al., "Polymers for Colon-Specific Drug Delivery," J. Controlled Release 19, 121–130 (1992).

40. A. Tursi et al., "Assessment of Orocaecal Transit Time in Different Localization of Crohn's Disease and Its Possible Influence on Clinical Response in Therapy," Eur. J. Gastroenterol. Hepatol. 15, 69–74 (2003).

41. C.K. Kim et al., "Trials of In Situ -Gelling and Mucoadhesive Acetaminophen Liquid Suppository in Human Subjects," Int. J. Pharm. 174, 201–207 (1998).

42. R. Yahagi, H. Onishi, and Y. Machida, "Preparation and Evaluation of Double-Phased Mucoadhesive Suppositories of Lidocaine Utilizing Carbopol and White Beeswax," J. Controlled Release 61, 1–8 (1999).

43. R. Yahagi et al., "Mucoadhesive Suppository of Ramosetron Hydrochloride Utilizing Carbopol.," Int. J. Pharm. 193, 205–212. (2000).

44. C.S. Yong et al., "Physicochemical Characterization and In Vivo Evaluation of Poloxamer-Based Solid Suppository Containing Diclofenac Sodium in Rats," Int. J. Pharm. 301, 54–61 (2005).

45. H.G. Choi ,Y.K. Oh, and C.K. Kim, "In Situ Gelling and Mucoadhesive Liquid Suppository Containing Acetaminophen: Enhanced Bioavailability," Int. J. Pharm. 165, 23–32 (1998).

46. M. Tang, P. Dettmar, and H. Batchelor, "Bioadhesive Oesophageal Bandages: Protection Against Acid and Pepsin Injury," Int. J. Pharm. 292, 169–177 (2005).

47. H.K. Batchelor et al., "Feasibility of a Bioadhesive Drug Delivery System Targeted to Esophageal Tissue," Eur. J. Pharm. Biopharm. 57, 295–298 (2004).

48. V. Vonarx et al., "Potential Efficacy of a Delta 5-Aminolevulinic Acid Bioadhesive Gel Formulation for the Photodynamic Treatment of Lesions of the Gastrointestinal Tract in Mice," J. Pharm. Pharmacol. 49, 652–656 (1997).

49. A.M. Potts et al., "Oesophageal Bandaging: A New Opportunity for Thermosetting Polymers," STP Pharma. Sci. 10, 293–301 (2001).

50. G. Ponchel, "Mucoadhesion of Colloidal Particulate Systems in the Gastrointestinal Tract," Eur. J. Pharm. Biopharm. 44, 25–31 (1997).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Jim Miller Outsourcing Outlook Jim MillerOutside Looking In
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAdvances in Large-Scale Heterocyclic Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler New Era for Generic Drugs
Sean Milmo European Regulatory WatchSean MilmoTackling Drug Shortages
New Congress to Tackle Health Reform, Biomedical Innovation, Tax Policy
Combination Products Challenge Biopharma Manufacturers
Seven Steps to Solving Tabletting and Tooling ProblemsStep 1: Clean
Legislators Urge Added Incentives for Ebola Drug Development
FDA Reorganization to Promote Drug Quality
Source: Pharmaceutical Technology,
Click here