Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems - Pharmaceutical Technology

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Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems
Novel hydrophobic bioadhesive polymers and dosage designs are now available to effectively achieve tailored release kinetics of a broad range of drugs to meet the clinical needs.


Pharmaceutical Technology
Volume 32, Issue 11, pp. 100-121

36. P. Moslemy et al., "Pharmacokinetic Studies with a Mucoadhesive Multilayer Extended Release Tablet Formulation of Levodopa-Carbidopa in Healthy Volunteers" in Proceedings of CRS Annual Meeting, Abstract #2499 (2007).

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38. L. Yang, J.S. Chu, and J.A. Fix, "Colon-Specific Drug Delivery: New Approaches and In Vitro–In Vivo Evaluation," Int. J. Pharm. 235, 1–15 (2002).

39. J. Kopecek et al., "Polymers for Colon-Specific Drug Delivery," J. Controlled Release 19, 121–130 (1992).

40. A. Tursi et al., "Assessment of Orocaecal Transit Time in Different Localization of Crohn's Disease and Its Possible Influence on Clinical Response in Therapy," Eur. J. Gastroenterol. Hepatol. 15, 69–74 (2003).

41. C.K. Kim et al., "Trials of In Situ -Gelling and Mucoadhesive Acetaminophen Liquid Suppository in Human Subjects," Int. J. Pharm. 174, 201–207 (1998).

42. R. Yahagi, H. Onishi, and Y. Machida, "Preparation and Evaluation of Double-Phased Mucoadhesive Suppositories of Lidocaine Utilizing Carbopol and White Beeswax," J. Controlled Release 61, 1–8 (1999).

43. R. Yahagi et al., "Mucoadhesive Suppository of Ramosetron Hydrochloride Utilizing Carbopol.," Int. J. Pharm. 193, 205–212. (2000).

44. C.S. Yong et al., "Physicochemical Characterization and In Vivo Evaluation of Poloxamer-Based Solid Suppository Containing Diclofenac Sodium in Rats," Int. J. Pharm. 301, 54–61 (2005).

45. H.G. Choi ,Y.K. Oh, and C.K. Kim, "In Situ Gelling and Mucoadhesive Liquid Suppository Containing Acetaminophen: Enhanced Bioavailability," Int. J. Pharm. 165, 23–32 (1998).

46. M. Tang, P. Dettmar, and H. Batchelor, "Bioadhesive Oesophageal Bandages: Protection Against Acid and Pepsin Injury," Int. J. Pharm. 292, 169–177 (2005).

47. H.K. Batchelor et al., "Feasibility of a Bioadhesive Drug Delivery System Targeted to Esophageal Tissue," Eur. J. Pharm. Biopharm. 57, 295–298 (2004).

48. V. Vonarx et al., "Potential Efficacy of a Delta 5-Aminolevulinic Acid Bioadhesive Gel Formulation for the Photodynamic Treatment of Lesions of the Gastrointestinal Tract in Mice," J. Pharm. Pharmacol. 49, 652–656 (1997).

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