Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems - Pharmaceutical Technology

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Science and Technology of Bioadhesive-Based Targeted Oral Delivery Systems
Novel hydrophobic bioadhesive polymers and dosage designs are now available to effectively achieve tailored release kinetics of a broad range of drugs to meet the clinical needs.


Pharmaceutical Technology
Volume 32, Issue 11, pp. 100-121

51. J.K. Vasir, K. Tambwekar, and S. Garg, "Bioadhesive Microspheres as a Controlled Drug Delivery System," Int. J. Pharm. 255, 13–32 (2003).

52. C.A. Santos et al., "Correlation of Two Bioadhesion Assays: The Everted Sac Technique and the CAHN Microbalance," J. Controlled Release 61, 113–122 (1999).

53. A. Lamprecht, U. Schafer, and C.M. Lehr, "Size-Dependent Bioadhesion of Micro- and Nanoparticulate Carrier to the Inflamed Colonic Mucosa," Pharm. Res. 18, 788–793 (2001).

54. K. Park and J.R. Robinson, "Bioadhesive Polymers as Platforms for Oral-Controlled Drug Delivery: Method to Study Bioadhesion," Int. J. Pharm. 19, 107–127 (1984).

55. S. Thairs et al., "Effect of Dose Size, Food and Surface Coating on the Gastric Residence and Distribution of an Ion Exchange Resin," Int. J. Pharm. 176, 47–53 (1998).

56. S. Furtado et al., "Oral Delivery of Insulin-Loaded Poly(fumaric-co-sebacic) Anhydride Microspheres," Int. J. Pharm. 347, 149–155 (2008).

57. M. Kreitz et al., "A Bioadhesive Nanoparticle Formulation for Improved Oral Delivery of Paclitaxel," in Proceedings of the Controlled Release Society's Annual Meeting (2004).

58. R.B. Umamaheshwari, S. Ramteke, and N.K. Jain, "Anti-Helicobacter Pylori Effect of Mucoadhesive Nanoparticles Bearing Amoxicillin in Experimental Gerbils Model," AAPS PharmSci. Tech. 5, 1–9 (2004).

59. A. Ahmed, C. Bonner and T.A. Desai, "Bioadhesive Microdevices with Multiple Reservoirs: A New Platform for Oral Drug Delivery," J. Controlled Release 81, 291–306 (2002)

60. S.L. Tao, M.W. Lubeley, and T.A. Desai, "Bioadhesive Poly(methyl methacrylate) Microdevices for Controlled Drug Delivery," J. Controlled Release 88, 215–228 (2003).

61. G.V. Betageri, D.V. Deshmukh, and R.B. Gupta, "Oral Sustained Release Bioadhesive Tablet Formulations of Didanosine," Drug Dev. Ind. Pharm. 27, 129–136 (2001).

62. A. Bernkop-Schnürch et al., "The Use of Thiolated Polymers as Carrier Matrix in Oral Peptide Delivery: Proof of Concept," J. Controlled Release 106, 26–33 (2005).

63. A. Nangia, "BIOROD Bioadhesive Based Oral Delivery System," Annual CRS International Symposium on Bioactive Materials, New York (2008) submitted abstract.

64. J.A. Champion, Y.K. Katare, and S. Mitragotri, "Particle Shape: A New Design Parameters for Micro- and Nanoscale Drug Delivery Carriers," J. Controlled Release 121, 3–9 (2007).

65. R. Khosla and S.S. David, "The Effect of Polycarbophil on the Gastric Emptying of Pellets," J. Pharm. Pharmacol 39, 47–49 (1987).


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