Formulation of Sustained-Release Ketorolac Tromethamine Pellets - Pharmaceutical Technology

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Formulation of Sustained-Release Ketorolac Tromethamine Pellets
The authors evaluated the effect of polymer composition on the drug-release profile and the effect of storage conditions on dissolution characteristics.


Pharmaceutical Technology
Volume 32, Issue 12, pp. 58-61

References

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4. J. Rovensky and D. Micekova, "Six-Month Prospective Study to Monitor the Treatment of Rheumatic Diseases with Sustained-Release Flurbiprofen," Drug. Exp. Clin. Res. 26, 19–24 (2000).

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6. L. Genc and N. Hegazy, "Sustained-Release Wax Matrix Formulations of Ketorolac Tromethamine with Compritol 888 ATO and HD 5 ATO," Acta Pharm. Turcia 42, 39–45 (2000).

7. D.M. Brahmankar, R.M. Karwa, and S.B. Jaiswal, "Cellulose Matrices for Controlled Release of Ketorolac Tromethamine," Indian Drugs 33, 120–123 (1996).

8. N. Vatsaraj, H. Zia, and T. Needham, "Formulation and Optimization of a Sustained-Release Tablet of Ketorolac Tromethamine," Drug Delivery 9, 153–159 (2002).

9. A.P. Rokhade et al., "Semi-Interpenetrating Polymer Network Microspheres of Gelatin and Sodium Carboxymethyl Cellulose for Controlled Release of Ketorolac Tromthamine," Carbohydrate Polymers 65, 243–252 (2006).

10. K. Ruckmani, M.S. Muneera, and R. Vijaya, "Eudragit Matrices for Sustained Release of Ketorolac Tromethamine and Kinetics of Release," Bollettino Chimico Farmaceutico 139, 205–208 (2000).

11. E.A. Hosny, A.A. Al-Helm, and E.M. Niazy, "In Vitro and In Vivo Evaluation of Commercial and Microcapsulated Sustained-Release Tablets Containing Diclofenac Sodium," Saudi Pharm. J. 6, 65–70 (1998).

12. M. Khan, J. Dib, and I.K. Reddy, "Statistical Optimization of Ketoprophen-Eudragit S-100 Coprecipitates to Obtain Controlled-Release Tablets," Drug Dev. Ind. Pharm. 22, 135–141 (1996).

13. C. Ho and G.C. Hwang, "Development of Extended-Release Solid Dispersions of Nonsteroidal Anti-Inflammatory Drugs with Aqueous Polymeric Dispersions: Optimization of Drug Release via a Curve-Fitting Technique," Pharm. Res. 9, 206–210 (1992).

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16. R.K. Chang and A.J. Shukla, "Polymethacrylates," in Handbook of Pharmaceutical Excipients, R.C. Rowe, P.J. Shesky, and P.J. Weller, Eds. (Pharmaceutical Press, 4th ed., London, England, 2002), pp. 462–468.

17. L. Genc, E. Guler, and N. Hegazy, "Film-Coated Enteric Tablet Formulation of Ketorolac Tromethamine," Drug Dev. Ind. Pharm. 23, 1007–1011 (1997).

18. T. Higuchi, "Mechanism of Sustained Action Medication. Theoretical Analysis of Rate Release of Solid Drugs Dispersed in Solid Matrices," J. Pharm. Sci. 52, 1145–1149 (1963).

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