Formulation of Sustained-Release Ketorolac Tromethamine Pellets - Pharmaceutical Technology

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Formulation of Sustained-Release Ketorolac Tromethamine Pellets
The authors evaluated the effect of polymer composition on the drug-release profile and the effect of storage conditions on dissolution characteristics.


Pharmaceutical Technology
Volume 32, Issue 12, pp. 58-61

References

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2. Physician's Desk Reference (Thomson PDR, 57th ed., Montvale, NJ, 2003), p. 2942.

3. M. Mori et al., "Prolongation of Antipyretic Action and Reduction of Gastric Ulcerogenicity in the Rat by Controlled-Release Granules of Bermoprofen, a New Nonsteroidal Anti-Inflammatory Drug," J. Pharm. Sci. 80, 876–880 (1991).

4. J. Rovensky and D. Micekova, "Six-Month Prospective Study to Monitor the Treatment of Rheumatic Diseases with Sustained-Release Flurbiprofen," Drug. Exp. Clin. Res. 26, 19–24 (2000).

5. T. Lee and J.R. Robinson, "Controlled-Release Drug-Delivery Systems," in Remington: The Science and Practice of Pharmacy (Lippincott Williams & Wilkins, 20th ed., Baltimore, MD, 2000), pp. 903–904.

6. L. Genc and N. Hegazy, "Sustained-Release Wax Matrix Formulations of Ketorolac Tromethamine with Compritol 888 ATO and HD 5 ATO," Acta Pharm. Turcia 42, 39–45 (2000).

7. D.M. Brahmankar, R.M. Karwa, and S.B. Jaiswal, "Cellulose Matrices for Controlled Release of Ketorolac Tromethamine," Indian Drugs 33, 120–123 (1996).

8. N. Vatsaraj, H. Zia, and T. Needham, "Formulation and Optimization of a Sustained-Release Tablet of Ketorolac Tromethamine," Drug Delivery 9, 153–159 (2002).

9. A.P. Rokhade et al., "Semi-Interpenetrating Polymer Network Microspheres of Gelatin and Sodium Carboxymethyl Cellulose for Controlled Release of Ketorolac Tromthamine," Carbohydrate Polymers 65, 243–252 (2006).

10. K. Ruckmani, M.S. Muneera, and R. Vijaya, "Eudragit Matrices for Sustained Release of Ketorolac Tromethamine and Kinetics of Release," Bollettino Chimico Farmaceutico 139, 205–208 (2000).

11. E.A. Hosny, A.A. Al-Helm, and E.M. Niazy, "In Vitro and In Vivo Evaluation of Commercial and Microcapsulated Sustained-Release Tablets Containing Diclofenac Sodium," Saudi Pharm. J. 6, 65–70 (1998).

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13. C. Ho and G.C. Hwang, "Development of Extended-Release Solid Dispersions of Nonsteroidal Anti-Inflammatory Drugs with Aqueous Polymeric Dispersions: Optimization of Drug Release via a Curve-Fitting Technique," Pharm. Res. 9, 206–210 (1992).

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16. R.K. Chang and A.J. Shukla, "Polymethacrylates," in Handbook of Pharmaceutical Excipients, R.C. Rowe, P.J. Shesky, and P.J. Weller, Eds. (Pharmaceutical Press, 4th ed., London, England, 2002), pp. 462–468.

17. L. Genc, E. Guler, and N. Hegazy, "Film-Coated Enteric Tablet Formulation of Ketorolac Tromethamine," Drug Dev. Ind. Pharm. 23, 1007–1011 (1997).

18. T. Higuchi, "Mechanism of Sustained Action Medication. Theoretical Analysis of Rate Release of Solid Drugs Dispersed in Solid Matrices," J. Pharm. Sci. 52, 1145–1149 (1963).

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21. R.C. George et al., "Investigation into the Yellowing on Aging of Sabril Tablet Cores," Drug Dev. Ind. Pharm. 20, 3023–3032 (1994).


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