The Rotation of Disinfectants Principle: True or False? - Pharmaceutical Technology

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The Rotation of Disinfectants Principle: True or False?
The author defines sanitizers, disinfectants, and antibiotics, and examines the question of whether the rotation of disinfectants is scientifically warranted.

Pharmaceutical Technology
Volume 33, Issue 2, pp. 58-71

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42. S.G. Geftic, H. Heymann, and F.W. Adair, "Fourteen-Year Survival of Pseudomonas cepacia in a Salts Solution Preserved with Benzalkonium Chloride," Appl. Environ. Microbiol. 37 (3), 505–510 (1979).

43. K. Sekimizu et al., "Increase in Resistance of Methicillin-Resistant Staphylococcus aureus to ß-lactams Caused by Mutations Conferring Resistance to Benzalkonium Chloride, a Disinfectant Widely Used in Hospitals," Antimicrob. Agents Chemother. 43 (12), 3042–3043 (1999).

44. J.A. Joynson, B. Forbes, and R.J.W. Lambert, "Adaptive Resistance to Benzalkonium Chloride, Amikacin, and Tobramycin: The Effect on Susceptibility to Other Antimicrobials," J. Appl. Microbiol. 93 (1), 96–107 (2002).

45. H.P. Schweizer et al., "Cross-Resistance between Triclosan and Antibiotics in Pseudomonas aeruginosa Is Mediated by Multidrug Efflux Pumps: Exposure of a Susceptible Mutant Strain to Triclosan Selects nfxB Mutants Overexpressing MexCD-Opr," Antimicrob. Agents Chemother. 45 (2), 428–432 (2001).


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