The Rotation of Disinfectants Principle: True or False? - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

The Rotation of Disinfectants Principle: True or False?
The author defines sanitizers, disinfectants, and antibiotics, and examines the question of whether the rotation of disinfectants is scientifically warranted.

Pharmaceutical Technology
Volume 33, Issue 2, pp. 58-71

46. G. Mayer, "Antibiotics that Affect the Cell Envelope" in Microbiology and Immunology, University of South Carolina,, accessed Jan. 18, 2009.

47. T. Montie and P. Patamasucon. "Aminoglycosides: the Complex Problem of Antibiotic Mechanisms and Clinical Applications," Eur. J. Clin. Microbiol. Infect. Dis. 14, 85–87 (1995).

48. H.J. Busse, C. Wostmann, and E.P. Bakker, "The Bactericidal Action of Streptomycin: Membrane Permeabilization Caused by the Insertion of Mistranslated Proteins into the Cytoplasmic Membrane of Escherichia coli and Subsequent Caging of the Antibiotic inside the Cells: Degradation of these Proteins," J. Gen. Microbiol. 138, 551–561 (1992).

49. H.F. Chambers and M.A. Sande, "Antimicrobial Agents: The Aminoglycosides," in The Pharmacological Basis of Therapeutics, J.G. Hardman et al., Eds. (McGraw-Hill, New York, 1995), pp. 1103–1121.

50. J. Davies and G. Wright, "Bacterial Resistance to Aminoglycoside Antibiotics," Trends Microbiol. 5, 234–239 (1997).

51. K.J. Shaw et al., "Molecular Genetics of Aminoglycoside Resistance Genes and Familial Relationships of the Aminoglycoside-Modifying Enzymes," Microbiol. Rev. 57, 138–163 (1993).

52. E.K. Manavathu et al., "Molecular Studies on the Mechanism of Tetracycline Resistance Mediated by Tet(O)," Antimicrob. Agents Chemother. 34, 71–77 (1990).

53. S.B. Levy et al., "Nomenclature for New Tetracycline Resistance Determinants," Antimicrob. Agents Chemother. 43, 1523–1524 (1999).

54. I. Chopra, "New Developments in Tetracycline Antibiotics: Glycylcyclines and Tetracycline Efflux Pump Inhibitors," Drug Resist. Updat. 5 (3–4), 119–125 (2002).

55. M.C. Roberts, "Tetracycline Resistant Determinants: Mechanisms of Action, Regulation of Expression, Genetic Mobility, and Distribution," FEMS Microbiol. Rev. 19, 1–24 (1996).

56. F. Schluenzen et al. "Structural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Centre in Eubacteria", Nature 413, 814–821 (2001).

57. R. Fernandez-Muñoz and D. Vazquez, "Kinetic Studies of Peptide Bond Formation: Effect of Chloramphenicol," Mol. Biol. Rep. 1, 75–79 (1973).

58. M. Michelinaki et al., "Aminoacyl and Peptidyl Analogs of Chloramphenicol as Slow-Binding Inhibitors of Ribosomal Peptidyltransferase: A New Approach for Evaluating Their Potency," Mol. Pharmacol. 51, 139–146 (1997).

59. M.A. Xaplanteri et al., "Effect of Polyamines on the Inhibition of Peptidyltransferase by Antibiotics: Revisiting the Mechanism of Chloramphenicol Action," Nucleic Acids Res. 31, 5074–5083 (2003).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Jim Miller Outsourcing Outlook Jim MillerCMO Industry Thins Out
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerFluorination Remains Key Challenge in API Synthesis
Marilyn E. Morris Guest EditorialMarilyn E. MorrisBolstering Graduate Education and Research Programs
Jill Wechsler Regulatory Watch Jill Wechsler Biopharma Manufacturers Respond to Ebola Crisis
Sean Milmo European Regulatory WatchSean MilmoHarmonizing Marketing Approval of Generic Drugs in Europe
FDA Reorganization to Promote Drug Quality
FDA Readies Quality Metrics Measures
New FDA Team to Spur Modern Drug Manufacturing
From Generics to Supergenerics
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Source: Pharmaceutical Technology,
Click here