The Rotation of Disinfectants Principle: True or False? - Pharmaceutical Technology

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PharmTech Europe

The Rotation of Disinfectants Principle: True or False?
The author defines sanitizers, disinfectants, and antibiotics, and examines the question of whether the rotation of disinfectants is scientifically warranted.


Pharmaceutical Technology
Volume 33, Issue 2, pp. 58-71

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78. C. Janoir et al., "High-Level Fluoroquinolone Resistance in Streptococcus pneumoniae Requires Mutations in parC and gyrA," AAC. 40, 2760–2764 (1996).

79. X.S. Pan and L.M. Fisher, "DNA Gyrase and Topoisomerase IV Are Dual Targets of Clinafloxacin Action in Streptococcus pneumoniae, " AAC. 42, 2810–2816 (1998).

80. H. Taba and N. Kusano, "Sparfloxacin Resistance in Clinical Isolates of Streptococcus pneumoniae : Involvement of Multiple Mutations in gyrA and parC Genes", AAC. 42, 2193–2196 (1998).

81. X. Zhao et al., "DNA Topoisomerse Targets of the Fluoroquinolones: A Strategy for Avoiding Bacterial Resistance," Proc. Natl. Acad. Sci. U.S.A. 94, 13991–13996 (1997).

82. D.C. Hooper, "Mode of Action of Fluoroquinolones," Drugs 58 (suppl 2), 6–10 (1999).

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