End-to-End Innovations - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

End-to-End Innovations
Integrated lines, flexible machines, and high-barrier materials enhance packaging options.

Pharmaceutical Technology
Volume 33, Issue 3, pp. 52-58


Pack Expo International also featured several materials of interest to pharmaceutical packagers. A new family of high-barrier metallized polyethylene terephthalate (PET) films serves as a low-cost, lightweight alternative to foil laminations. A 36-gauge metallized PET can replace a 48-gauge foil lamination, which could be expensive and complex. The metallized film bolsters source-reduction efforts by eliminating the need for a sealant layer. Resistant to delamination and compatible with hard-to-hold products, the thin, multilayer films offer oxygen-transmission rates ranging from < 0.01 to 0.15 cm3/100 in.2/day and water-vapor transmission rates ranging from 0.03 to 0.15 g/100 in.2/day ("LumLife MK" PET film, Toray Plastics America, North Kingstown, RI).

Another potential foil replacement is a clear film that offers a strong barrier to oxygen and moisture. The product combines an polychlorotrifluoroethylene (PCTFE) fluoropolymer layer and a polyvinylidene chloride (PVDC) coating. The four-layer polyvinyl chloride (PVC)–PVDC–PCTFE–PVC structure is designed for the most sensitive pharmaceuticals and nutraceuticals. Because PVC is the contact layer, the film does not require special tooling on form–fill–seal equipment. Also available in an opaque version, the film exhibits excellent lay-flat characteristics ("Pentapharm kpMax" films, Klöckner Pentaplast Group, Gordonsville, VA).

A new solvent-free foil lamination designed especially for pharmaceutical overwrap applications is an extrusion-coated 48-gauge PET–low-density polyethylene–35-gauge foil–metallocene PE structure. Despite a significantly thinner sealant layer than competing materials, the metallocene PE forms stronger weld seals at speeds higher than 100 ft/min. Typical applications include secondary packaging for blow–fill–seal unit-dose containers for inhalation therapy or diagnostic kits. Reverse- or surface-printed white or natural foil structure can be supplied in rollstock form or as premade pouches or die-cut lids ("Triad" foil lamination, Rollprint Packaging Products, Addison, IL).

Hallie Forcinio is Pharmaceutical Technology's Packaging Forum editor, 4708 Morningside Drive, Cleveland, OH 44109, tel. 216.351.5824, fax 216.351.5684,


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
View Results
Eric Langerr Outsourcing Outlook Eric LangerTargeting Different Off-Shore Destinations
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAsymmetric Synthesis Continues to Advance
Jill Wechsler Regulatory Watch Jill Wechsler Data Integrity Key to GMP Compliance
Sean Milmo European Regulatory WatchSean MilmoExtending the Scope of Pharmacovigilance Comes at a Price
From Generics to Supergenerics
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Ebola Outbreak Raises Ethical Issues
Better Comms Means a Fitter Future for Pharma, Part 2: Realizing the Benefits of Unified Communications
Better Comms Means a Fitter Future for Pharma, Part 1: Challenges and Changes
Source: Pharmaceutical Technology,
Click here