A Novel Pregelatinized Starch as a Sustained-Release Matrix Excipient - Pharmaceutical Technology

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A Novel Pregelatinized Starch as a Sustained-Release Matrix Excipient
The authors examine the use of a novel highly functional pregelatinized starch as a controlled-release matrix excipient.

Pharmaceutical Technology


The authors conclude that HS can be applied for the development of sustained-release tablets. Experimental data confirmed the following points:

  • Drug release from HS matrix tablets was well controlled under conditions of high ionic strength and high mechanical force
  • The zero-order drug-release profile can be obtained by using a mixture of HS and PEG and is independent from drug solubility
  • The HS matrix tablets show stable drug-release profiles even under accelerated conditions
  • HS is a new matrix excipient that can control drug-release profiles from first- to zero-order sustained release and enables drug release independent of drug solubility and external conditions.

Masaaki Endo is an engineer, Kazuhiro Obae* is a chief engineer, and Yoshihito Yaginuma is a general manager, all in the Ceolus Research and Development Department at Asahi Kasei Chemicals Corporation, 1-105 Kanda Jinbocho, Chiyoda-ku, Tokyo 101-8101 Japan,

*To whom all correspondence should be addressed.


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9. M. Endo, K. Obae, and Y. Yaginuma, "Application of Novel Pregelatinzed Starch as a Sustained Release Matrix Carrier,'' presented at the American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Nashville, TN, Oct. 6–10, 2005.

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