Large-Scale Manufacture of Therapeutic Human Stem Cells - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Large-Scale Manufacture of Therapeutic Human Stem Cells
Large-scale manufacturing of human stem cells for therapeutic use is a leap in technology and science for the current biotechnology industry.


Pharmaceutical Technology
Volume 33, Issue 7, pp. 74-79

Robert J. Thomas* is a Research Councils UK academic fellow in biomanufacturing, and David J. Williams is the professor of healthcare engineering and director of the Research School of Health and Life Sciences, both at Loughborough University, Loughborough, UK, LE11 3TU, tel. +44 1509 227601,

*To whom all correspondence should be addressed.




What would you do differently? Submit your comments about this paper in the space below.

References

1. M.J. Lysaught, A. Jaklenec, and E. Deweerd, "Great Expectations: Private Sector Activity in Tissue Engineering, Regenerative Medicine, and Stem Cell Therapeutics," Tissue Engin., 14 (Part A), 305–315 (2008).

2. R. Archer and D.J. Williams, "Why Tissue Engineering Needs Process Engineering," Nature Biotechnol., 23 (11), 1353–1355 (2005).

3. C. Allegrucci, Y.Z. Wu, and A. Thurston, "Restriction Landmark Genome Scanning Identifies Culture-Induced DNA Methylation Instability in the Human Embryonic Stem Cell Epigenome," Human Molec. Gen. 16 (10), 1253–1268 (2007b).

4. D. Brafman et al., "Defining Long-Term Maintenance Conditions of Human Embryonic Stem Cells with Arrayed Cellular Microenvironment Technology," Stem Cells Develop., electronic publication ahead of print (2009).

5. D. Van Hoof, A.J. Heck, J. Krijgsveld, and C.L. Mummery, "Proteomics and Human Embryonic Stem Cells," Stem Cell Res., 1 (3), 169–182 (2008).

6. M.S. Bodnar, J.J. Meneses, R.T. Rodriguez, and M.T. Firpo, Propagation and Maintenance of Undifferentiated Human Embryonic Stem Cells," Stem Cells Develop., 13 (3), 243–253 (2004).

7. R. J. Thomas et al., "Manufacture of a Human Mesenchymal Stem Cell Population Using an Automated Cell Culture Platform," Cytotechnol., 55 (1), 31–39 (2007).

8. R.J. Thomas et al., "Automated, Scalable Culture of Human Embryonic Stem Cells in Feeder-Free Conditions," Biotechnol. Bioengin., 102 (6), 1636–44 (2009).

9. R.J. Thomas et al., "Automated, Serum-Free Production of CTX0E03: A Therapeutic Clinical Grade Human Neural Stem Cell Line," Biotechnolo. Letters, electronic publication ahead of print (2009).

10. R.J. Thomas, P.C. Hourd, and D.J. Williams, "Application of Process Quality Engineering Techniques to Improve the Understanding of the in vitro Processing of Stem Cells for Therapeutic Use," Jrnl. of Biotechnol., 136 (3–4), 148–155 (2008).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
23%
Oversee medical treatment of patients in the US.
14%
Provide treatment for patients globally.
7%
All of the above.
47%
No government involvement in patient treatment or drug development.
9%
Jim Miller Outsourcing Outlook Jim MillerOutside Looking In
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAdvances in Large-Scale Heterocyclic Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler New Era for Generic Drugs
Sean Milmo European Regulatory WatchSean MilmoTackling Drug Shortages
New Congress to Tackle Health Reform, Biomedical Innovation, Tax Policy
Combination Products Challenge Biopharma Manufacturers
Seven Steps to Solving Tabletting and Tooling ProblemsStep 1: Clean
Legislators Urge Added Incentives for Ebola Drug Development
FDA Reorganization to Promote Drug Quality
Source: Pharmaceutical Technology,
Click here