Novel Approaches for Oral Insulin Delivery - Pharmaceutical Technology

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Novel Approaches for Oral Insulin Delivery
The authors review various oral drug delivery systems that have been explored to increase patient compliance for insulin.


Pharmaceutical Technology
Volume 33, Issue 7

18. A.M. Lowman, "Oral Delivery of Insulin using pH-Sensitive Complexation Gels," J. Pharm. Sci. 88 (9), 933–937 (1999).

19. N.A. Peppas, "Devices based on Intelligent Biopolymers for Oral Protein Delivery," Int. J. Pharm. 277 (1–2), 11–17 (2004).

20. C. Ramkisson-Ganorkar, "Modulating Insulin Release Profile from pH/Thermosensitive Polymeric Beads through Polymer Molecular Weight," J. Control. Release 59 (3), 287–298 (1999).

21. K. Zhang and X.Y. Wu, "Temperature and pH Responsive Polymeric Composite Membranes for Controlled Delivery of Proteins and Peptides," Biomaterials 25 (22), 5281–5291 (2004).

22. C.P. Reis et al., "Alginate Microparticles as Novel Carrier for Oral Insulin Delivery," Biotechnol. Bioeng. 96 (5), 977–989 (2007).

23. H. Tozaki, "Chitosan Capsules for Colon-Specific Drug Delivery: Improvement of Insulin Absorption from the Rat Colon," J. Pharm. Sci. 86 (9), 1016–1021 (1997).

24. U. Ubaidulla et al., "Chitosan Phthalate Microspheres for Oral Delivery of Insulin: Preparation, Characterization, and In Vitro Evaluation," Drug Delivery 14 (1), 19–23 (2007).

25. R. Qi and Q.N. Ping, "Gastrointestinal Absorption Enhancement of Insulin by Administration of Enteric Microspjeres and SNAC to Rats," J. Microencapsul. 21 (1), 37–45 (2004).

26. D. Senthil Rajan et al., "Oral Delivery System of Insulin Microspheres: Effect on Relative Hypoglycemia of Diabetic Albino Rats," Boll. Chim. Farm. 143 (8), 315–318 (2004).

27. B.Y. Kim et al., "Bioadhesive Interaction and Hypoglycemic Effect of Insulin-Loaded Lectin-Microparticle Conjugates in Oral Insulin Delivery System," J. Control. Release 102 (3), 525–38 (2005).

28. K.B. Choudhari and V. Labhasetwar, "Liposomes as a Carrier for Oral Administration of Insulin: Effect of Formulation Factors," J. Microencapsul. 11 (3), 319–325 (1994).

29. Z.H. Wu, "Hypoglyceamic Efficacy of Chitosan-Coated Insulin Liposomes after Oral Administration in Mice," Acta Pharmacol Sin. 25 (7), 966–972 (2004).

30. D. Cantenys et al., "Covalent Attachment of Insulin to the Outer Surface of Liposomes," Biochem. Biophys. Res. Commun. 117 (2), 399–405 (1983).

31. Q. Ye et al., "DepoFoam Technology: A Vehicle for Controlled Delivery of Protein and Peptide Drugs," J. Control. Release 14, (1–3), 155–66 (2000).

32. Z.H. Wu et al., "Studies on the Insulin-Liposomes Double-Coated by Chitosan and Chitosan-EDTA Conjugates," Yao Xue Xue Bao 39 (11), 933-938 (2004).


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