Novel Approaches for Oral Insulin Delivery - Pharmaceutical Technology

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Novel Approaches for Oral Insulin Delivery
The authors review various oral drug delivery systems that have been explored to increase patient compliance for insulin.


Pharmaceutical Technology
Volume 33, Issue 7

33. N. Zhang et al., "Investigation of Lectin-Modified Insulin Liposomes as Carriers for Oral Administration," Int. J. Pharm. 294 (1–2), 247–59 (2005).

34. M. Ramadas et al., "Lipoinsulin Encapsulated Alginate-Chitosan Capsules: Intestinal Delivery in Diabetic Rats," J. Microencapsul. 17 (4), 405–411 (2000).

35. D. Attivi et al., "Formulation of Insulin-Loaded Polymeric Nanoparticles using Response Surface Methodology," Drug Dev. Ind. Pharm. 31 (2), 179–189 (2005).

36. D.R. Bhumkar et al., "Chitosan-Reduced Gold Nanoparticles as Novel Carriers for Transmucosal Delivery of Insulin," Pharm. Res. 23 (2007).

37. C. Damge et al., "Poly (alkyl cyanoacrylate) Nanospheres for Oral Adminiatration of Insulin," J Pharm Sci. 86 1403–1409 (1997).

38. C. Damge, P. Maincent, and N. Ubrich, "Oral Delivery of Insulin Associated to Polymeric Nanoparticles in Diabetic Rats," J Control Release 117 (2), 163–170, Epub 2006 (2007).

39. K.B. Chalasani et al., "A Novel Vitamin B12-Nanosphere Conjugate Carrier System for Peroral Delivery of Insulin," J Control Release 117 (3), 421–429 Epub 2006, (2007).

40. Y.H. Lin et al., "Preparation and Characterization of Nanoparticles Shelled with Chitosan for Oral Insulin Delivery," Biomacromolecules 8 (1), 146–152. (2007).

41. F.D. Cui et al., "Preparation of Insulin-Loaded PLGA-Hp55 Nanoparticles for Oral Delivery," J. Pharm Sci. 96 (2), 421–427. (2007).

42. B. Sarmento et al., "Development and Characterization of New Insulin Containing Polysaccharide Nanoparticles," Colloids Surf B. Biointerfaces 53 (2), 193–202, (2006).

43. W. Tiyaboonchai et al., "Insulin Containing Polyethylenimine-Dextran Sulfate Nanoparticles," Int. J. Pharm. 255 (1–2), 139–51 (2006).

44. M. Simon et al., "Nanosized Insulin-Complexes based on BioDegradable Amine-Modified Graft Polyesters Poly(vinyl-3-(diethylamino)-propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft-poly(l-lactic acid): Protection Against Enzymatic Degradation, Interaction with Caco-2 Cell Monolayers, Peptide Transport and Cytotoxicity," Eur. J. Pharm. Biopharm. 66 (2), 165–172 (2007).

45. H. Tozaki et al., "Enhanced Absorption of Insulin and (Asu(1,7))eel-calcitonin Using Novel Azopolymer-Coated Pellets for Colon-Specific Drug Delivery," J. Pharm. Sci. 90 (1), 89–97 (2001).

46. H. Ichikawa and Y. Fukumori, "Design of Nanohydrogel-Incorporated Microcapsules for Appropriate Controlled-Release of Peptide Drugs," Yakugaku Zasshi 127 (5), 813–823 (2007).

47. K. Whitehead, Z. Shen, and S. Mitragotri, "Oral Delivery of Macromolecules Using Intestinal Patches: Applications for Insulin Delivery," J. Control. Release 98 (1), 37–45 (2004).


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