Novel Approaches for Oral Insulin Delivery - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Novel Approaches for Oral Insulin Delivery
The authors review various oral drug delivery systems that have been explored to increase patient compliance for insulin.


Pharmaceutical Technology
Volume 33, Issue 7

48. N.K. Raj and C.P. Sharma, "Oral Insulin: A Perspective," J Biomater Appl 17 (3), 183–96 (2003).

49. A.H. Krauland, D. Guggi, and A. Bernkop-Schnurch, "Oral Insulin Delivery: The Potential of Thiolated Chitosan-Insulin Tablets on Nondiabetic Rats," J Control Release 95 (3), 547–55 (2004).

50. F.A. Dorkoosh et al., "Peroral Delivery Systems based on Superporous Hydrogel Polymers: Release Characteristics for the Peptide Drugs Buserelin, Octreotide and Insulin," Eur J Pharm Sci 15 (5), 433-439 (2002).

51 . N.J. Kavimandan et al., "Synthesis and Characterization of Insulin-Transferrin Conjugates," Bioconjug Chem. 17 (6), 1376–1384. (2006).

52. H. Chung et al. "Self-Assembled 'Nanocubicle' as a Carrier for Peroral Insulin Delivery," Diabetologia 45 (3), 448–451 (2004).

53. A. Cilek et al., "A Lecithin-Based Microemulsion of rh-insulin with Aprotinin for Oral Administration: Investigation of Hypoglycemic Effects in Nondiabetic and STZ-Induced Diabetic Rats," Int J Pharm 298 (1), 176–85 (2005).

54. H.O. Ho, C.C. Hsiao, and M.T. Sheu, "Preparation of Microemulsions Using Polyglycerol Fatty Acid Esters as Surfactant for the Delivery of Protein Drugs," J Pharm Sci 85 (2), 138–143 (1996).

55. E.L. Ma et al., "In Vitro and In Vivo Evaluation of a Novel Oral Insulin Formulation," Acta Pharmacol Sin. 27 (10), 1382–1388. (2006).

56. W.A. Ritschel, "Microemulsions for Improved Peptide Absorption from the Gastrointestinal Tract," Methods Find Exp Clin Pharmacol 13 (3), 205–20 (1991).

57. M.E. Kraeling and W.A. Ritschel, "Development of a Colonic Release Capsule Dosage Form and the Absorption of Insulin," Methods Find Exp Clin Pharmacol 14 (3), 199–209 (1992).

58. A. Al-Achi and R. Greenwood, "Erythrocytes as Oral Delivery Systems for Human Insulin," Drug Dev Ind Pharm 24 (1), 67–72 (1998).

59. J. Varshosaz et al., "Development and Physical Characterization of Sorbitan Monoester Niosomes for Insulin Oral Delivery," Drug Deliv 10 (4), 251–62 (2003).

60. M. Trotta et al., "Solid Lipid Microparticles Carrying Insulin formed by Solvent-in-Water Emulsion-Diffusion Technique," Int J Pharm 288 (2), 281–288 (2005).

61. V. Aggarwal and M. Khan, "Current Status of the Oral Delivery of Insulin," Pharm. Technol. 76–90 (2001).

62. R. Langer, "Drug Delivery and Targetting," Nature 392 5–10 (1998).

63. H. Chen, V. Torchillin, and R. Langer, "Lecithin-Bearing Polymerised Liposomes as Potential Oral Vaccine Carriers," Pharm Res. 13 1378–1383 (1996).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
24%
Attracting a skilled workforce
30%
Obtaining/maintaining adequate financing
15%
Regulatory compliance
30%
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatcchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Obama Administration Halts Attack on Medicare Drug Plans
Source: Pharmaceutical Technology,
Click here