Novel Approaches for Oral Insulin Delivery - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Novel Approaches for Oral Insulin Delivery
The authors review various oral drug delivery systems that have been explored to increase patient compliance for insulin.


Pharmaceutical Technology
Volume 33, Issue 7

48. N.K. Raj and C.P. Sharma, "Oral Insulin: A Perspective," J Biomater Appl 17 (3), 183–96 (2003).

49. A.H. Krauland, D. Guggi, and A. Bernkop-Schnurch, "Oral Insulin Delivery: The Potential of Thiolated Chitosan-Insulin Tablets on Nondiabetic Rats," J Control Release 95 (3), 547–55 (2004).

50. F.A. Dorkoosh et al., "Peroral Delivery Systems based on Superporous Hydrogel Polymers: Release Characteristics for the Peptide Drugs Buserelin, Octreotide and Insulin," Eur J Pharm Sci 15 (5), 433-439 (2002).

51 . N.J. Kavimandan et al., "Synthesis and Characterization of Insulin-Transferrin Conjugates," Bioconjug Chem. 17 (6), 1376–1384. (2006).

52. H. Chung et al. "Self-Assembled 'Nanocubicle' as a Carrier for Peroral Insulin Delivery," Diabetologia 45 (3), 448–451 (2004).

53. A. Cilek et al., "A Lecithin-Based Microemulsion of rh-insulin with Aprotinin for Oral Administration: Investigation of Hypoglycemic Effects in Nondiabetic and STZ-Induced Diabetic Rats," Int J Pharm 298 (1), 176–85 (2005).

54. H.O. Ho, C.C. Hsiao, and M.T. Sheu, "Preparation of Microemulsions Using Polyglycerol Fatty Acid Esters as Surfactant for the Delivery of Protein Drugs," J Pharm Sci 85 (2), 138–143 (1996).

55. E.L. Ma et al., "In Vitro and In Vivo Evaluation of a Novel Oral Insulin Formulation," Acta Pharmacol Sin. 27 (10), 1382–1388. (2006).

56. W.A. Ritschel, "Microemulsions for Improved Peptide Absorption from the Gastrointestinal Tract," Methods Find Exp Clin Pharmacol 13 (3), 205–20 (1991).

57. M.E. Kraeling and W.A. Ritschel, "Development of a Colonic Release Capsule Dosage Form and the Absorption of Insulin," Methods Find Exp Clin Pharmacol 14 (3), 199–209 (1992).

58. A. Al-Achi and R. Greenwood, "Erythrocytes as Oral Delivery Systems for Human Insulin," Drug Dev Ind Pharm 24 (1), 67–72 (1998).

59. J. Varshosaz et al., "Development and Physical Characterization of Sorbitan Monoester Niosomes for Insulin Oral Delivery," Drug Deliv 10 (4), 251–62 (2003).

60. M. Trotta et al., "Solid Lipid Microparticles Carrying Insulin formed by Solvent-in-Water Emulsion-Diffusion Technique," Int J Pharm 288 (2), 281–288 (2005).

61. V. Aggarwal and M. Khan, "Current Status of the Oral Delivery of Insulin," Pharm. Technol. 76–90 (2001).

62. R. Langer, "Drug Delivery and Targetting," Nature 392 5–10 (1998).

63. H. Chen, V. Torchillin, and R. Langer, "Lecithin-Bearing Polymerised Liposomes as Potential Oral Vaccine Carriers," Pharm Res. 13 1378–1383 (1996).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
How does your company apply quality-by-design (QbD) principles to manufacturing processes?
To all processes for both new and legacy products
To all process for new products only
To select process for new products only
To select processes for both new and legacy products
Do not use QbD
To all processes for both new and legacy products
18%
To all process for new products only
13%
To select process for new products only
22%
To select processes for both new and legacy products
22%
Do not use QbD
24%
View Results
UPCOMING CONFERENCES

Programs for Investigational and Pre-Launch Drugs
Philadelphia, PA
July 17-18, 2013
Request Brochure

Strategic Pipeline Planning & Portfolio Valuation
Philadelphia, PA
August 13-14, 2013
Request Brochure

MES 2013 - Forum on Manufacturing Execution Systems
Philadelphia, PA
August 14-15, 2013
Request Brochure

Mobile Innovation for the Life Sciences Industry
Philadelphia, PA
August 20-21, 2013
Request Brochure

See All Conferences >>

Eric Langer Outsourcing Outlook Eric LangerOutsourcing's Modest Role as a Cost-Containment Strategy
Patricia Van Arnum Ingredients Insider Patricia Van ArnumIntellectual Property Battles in Solid-State Chemistry
Nathan Jessop Industry Insider Nathan Jessop Campaign Against Counterfeit Drugs Continues
Lynn Torbeck Statistical Solutions Lynn D. TorbeckCompositing Samples and the Risk to Product Quality
 More
Inadequate Access to Medicines Puts EU at Risk
FDA Offers Insight on QbD for Modified-Release Products
Global Biosimilars Market to Reach $2.445 Billion in 2013
Adapting to Change
AstraZeneca and Exco InTouch Collaborate to Augment Current COPD Pathways
FindPharma Custom Search
Source: Pharmaceutical Technology,
Click here