Formulation and Process Optimization of Cinnarizine Fast-Release Tablets - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Formulation and Process Optimization of Cinnarizine Fast-Release Tablets
The authors prepared granules containing cinnarizine using polyethylene glycol 6000 as a melting binder and lactose monohydrate as hydrophilic filler. The effects of binder concentration and size were studied.


Pharmaceutical Technology
Volume 33, Issue 8, pp. 53-59

5. M. Kidokoro et al., "Effect of Crystallization Behavior of Polyethylene Glycol 6000 on the Properties of Granule Prepared by Fluidized Hot Melt Granulation (FHMG)," Chem. Pharm. Bull. 51 (5), 487–493 (2003).

6. M.J. Hounslow, H.S. Tan, and A.D. Salman, "Kinetics of Fluidised Bed Melt Granulation V: Simultaneous Modelling of Aggregation and Breakage," Chem. Eng. Sci. 60 (14), 3847–3866 (2005).

7. K.J. Crowley et al., "Drug-Fatty Acid Salt with Wax-Like Properties Employed as Binder in Melt Granulation," Int. J. Pharm. 211, 9–17 (2000).

8. N. Passerini et al., "Characterization of Carbamazepine–Gelucire 50/13 Microparticles Prepared by a Spray Congealing Process using Ultrasounds," J. Pharm Sci. 91 (3), 699–707 (2002).

9. D. Rao et al., "Using a Novel Multicompartment Dissolution System to Predict the Effect of Gastric pH on the Oral Absorption of Weak Bases with Poor Intrinsic Solubility," J. Pharm. Sci. 94 (1), 199–208 (2005).

10. Y. Machida et al., "Preparation and Evaluation of Intragastric Buoyant Preparations," Drug Des. Del. 4, 155–161 (1989).

11. C.O. Agbada and P. York, "Dehydration of Theophylline Monohydrate Powder Effects of Particle Size and Sample Weight," Int. J. Pharm. 106, 33–40 (1994).

12. M.U. Uhumwangho and R.S. Okor, "Effect of Matrix Granulation and Wax Coating on the Dissolution Rates of Paracetamol Granules," African J. Biotech. 5 (9), 766–769 (2006).

13. S. Shamkant et al., "Application of Polyglycolized Glycerides in Protection of Amorphous Form of Etoricoxib during Compression," Chem. Pharm. Bull. 55 (10), 1448–1451 (2007).

14. A. Mansoor and F. Stepanek, "Formation of Hollow Core Granules by Fluid Bed In Situ Melt Granulation: Modelling and Experiments," Int. J. Pharm. 321, 108–116 (2006).

15. H.S. Tan, A.D. Salman, and M.J. Hounslow, "Kinetics of Fluidised Bed Melt Granulation I: The Effect of Process Variables," Chem. Eng. Sci. 61, 1585–1601 (2006).

16. A.D. Salman, H.S. Tan, and M.J. Hounslow, "Kinetics of Fluidised bed Melt Granulation IV: Selecting the Breakage Model," Powder Technol. 143, 65–83 (2004).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
23%
Oversee medical treatment of patients in the US.
14%
Provide treatment for patients globally.
7%
All of the above.
47%
No government involvement in patient treatment or drug development.
9%
Jim Miller Outsourcing Outlook Jim MillerOutside Looking In
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAdvances in Large-Scale Heterocyclic Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler New Era for Generic Drugs
Sean Milmo European Regulatory WatchSean MilmoTackling Drug Shortages
New Congress to Tackle Health Reform, Biomedical Innovation, Tax Policy
Combination Products Challenge Biopharma Manufacturers
Seven Steps to Solving Tabletting and Tooling ProblemsStep 1: Clean
Legislators Urge Added Incentives for Ebola Drug Development
FDA Reorganization to Promote Drug Quality
Source: Pharmaceutical Technology,
Click here