Formulation and Process Optimization of Cinnarizine Fast-Release Tablets - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Formulation and Process Optimization of Cinnarizine Fast-Release Tablets
The authors prepared granules containing cinnarizine using polyethylene glycol 6000 as a melting binder and lactose monohydrate as hydrophilic filler. The effects of binder concentration and size were studied.


Pharmaceutical Technology
Volume 33, Issue 8, pp. 53-59

5. M. Kidokoro et al., "Effect of Crystallization Behavior of Polyethylene Glycol 6000 on the Properties of Granule Prepared by Fluidized Hot Melt Granulation (FHMG)," Chem. Pharm. Bull. 51 (5), 487–493 (2003).

6. M.J. Hounslow, H.S. Tan, and A.D. Salman, "Kinetics of Fluidised Bed Melt Granulation V: Simultaneous Modelling of Aggregation and Breakage," Chem. Eng. Sci. 60 (14), 3847–3866 (2005).

7. K.J. Crowley et al., "Drug-Fatty Acid Salt with Wax-Like Properties Employed as Binder in Melt Granulation," Int. J. Pharm. 211, 9–17 (2000).

8. N. Passerini et al., "Characterization of Carbamazepine–Gelucire 50/13 Microparticles Prepared by a Spray Congealing Process using Ultrasounds," J. Pharm Sci. 91 (3), 699–707 (2002).

9. D. Rao et al., "Using a Novel Multicompartment Dissolution System to Predict the Effect of Gastric pH on the Oral Absorption of Weak Bases with Poor Intrinsic Solubility," J. Pharm. Sci. 94 (1), 199–208 (2005).

10. Y. Machida et al., "Preparation and Evaluation of Intragastric Buoyant Preparations," Drug Des. Del. 4, 155–161 (1989).

11. C.O. Agbada and P. York, "Dehydration of Theophylline Monohydrate Powder Effects of Particle Size and Sample Weight," Int. J. Pharm. 106, 33–40 (1994).

12. M.U. Uhumwangho and R.S. Okor, "Effect of Matrix Granulation and Wax Coating on the Dissolution Rates of Paracetamol Granules," African J. Biotech. 5 (9), 766–769 (2006).

13. S. Shamkant et al., "Application of Polyglycolized Glycerides in Protection of Amorphous Form of Etoricoxib during Compression," Chem. Pharm. Bull. 55 (10), 1448–1451 (2007).

14. A. Mansoor and F. Stepanek, "Formation of Hollow Core Granules by Fluid Bed In Situ Melt Granulation: Modelling and Experiments," Int. J. Pharm. 321, 108–116 (2006).

15. H.S. Tan, A.D. Salman, and M.J. Hounslow, "Kinetics of Fluidised Bed Melt Granulation I: The Effect of Process Variables," Chem. Eng. Sci. 61, 1585–1601 (2006).

16. A.D. Salman, H.S. Tan, and M.J. Hounslow, "Kinetics of Fluidised bed Melt Granulation IV: Selecting the Breakage Model," Powder Technol. 143, 65–83 (2004).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
24%
Oversee medical treatment of patients in the US.
12%
Provide treatment for patients globally.
10%
All of the above.
44%
No government involvement in patient treatment or drug development.
10%
Jim Miller Outsourcing Outlook Jim MillerCMO Industry Thins Out
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerFluorination Remains Key Challenge in API Synthesis
Marilyn E. Morris Guest EditorialMarilyn E. MorrisBolstering Graduate Education and Research Programs
Jill Wechsler Regulatory Watch Jill Wechsler Biopharma Manufacturers Respond to Ebola Crisis
Sean Milmo European Regulatory WatchSean MilmoHarmonizing Marketing Approval of Generic Drugs in Europe
FDA Reorganization to Promote Drug Quality
FDA Readies Quality Metrics Measures
New FDA Team to Spur Modern Drug Manufacturing
From Generics to Supergenerics
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Source: Pharmaceutical Technology,
Click here