Formulation and Process Optimization of Cinnarizine Fast-Release Tablets - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Formulation and Process Optimization of Cinnarizine Fast-Release Tablets
The authors prepared granules containing cinnarizine using polyethylene glycol 6000 as a melting binder and lactose monohydrate as hydrophilic filler. The effects of binder concentration and size were studied.


Pharmaceutical Technology
Volume 33, Issue 8, pp. 53-59

5. M. Kidokoro et al., "Effect of Crystallization Behavior of Polyethylene Glycol 6000 on the Properties of Granule Prepared by Fluidized Hot Melt Granulation (FHMG)," Chem. Pharm. Bull. 51 (5), 487–493 (2003).

6. M.J. Hounslow, H.S. Tan, and A.D. Salman, "Kinetics of Fluidised Bed Melt Granulation V: Simultaneous Modelling of Aggregation and Breakage," Chem. Eng. Sci. 60 (14), 3847–3866 (2005).

7. K.J. Crowley et al., "Drug-Fatty Acid Salt with Wax-Like Properties Employed as Binder in Melt Granulation," Int. J. Pharm. 211, 9–17 (2000).

8. N. Passerini et al., "Characterization of Carbamazepine–Gelucire 50/13 Microparticles Prepared by a Spray Congealing Process using Ultrasounds," J. Pharm Sci. 91 (3), 699–707 (2002).

9. D. Rao et al., "Using a Novel Multicompartment Dissolution System to Predict the Effect of Gastric pH on the Oral Absorption of Weak Bases with Poor Intrinsic Solubility," J. Pharm. Sci. 94 (1), 199–208 (2005).

10. Y. Machida et al., "Preparation and Evaluation of Intragastric Buoyant Preparations," Drug Des. Del. 4, 155–161 (1989).

11. C.O. Agbada and P. York, "Dehydration of Theophylline Monohydrate Powder Effects of Particle Size and Sample Weight," Int. J. Pharm. 106, 33–40 (1994).

12. M.U. Uhumwangho and R.S. Okor, "Effect of Matrix Granulation and Wax Coating on the Dissolution Rates of Paracetamol Granules," African J. Biotech. 5 (9), 766–769 (2006).

13. S. Shamkant et al., "Application of Polyglycolized Glycerides in Protection of Amorphous Form of Etoricoxib during Compression," Chem. Pharm. Bull. 55 (10), 1448–1451 (2007).

14. A. Mansoor and F. Stepanek, "Formation of Hollow Core Granules by Fluid Bed In Situ Melt Granulation: Modelling and Experiments," Int. J. Pharm. 321, 108–116 (2006).

15. H.S. Tan, A.D. Salman, and M.J. Hounslow, "Kinetics of Fluidised Bed Melt Granulation I: The Effect of Process Variables," Chem. Eng. Sci. 61, 1585–1601 (2006).

16. A.D. Salman, H.S. Tan, and M.J. Hounslow, "Kinetics of Fluidised bed Melt Granulation IV: Selecting the Breakage Model," Powder Technol. 143, 65–83 (2004).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
How does your company apply quality-by-design (QbD) principles to manufacturing processes?
To all processes for both new and legacy products
To all process for new products only
To select process for new products only
To select processes for both new and legacy products
Do not use QbD
To all processes for both new and legacy products
21%
To all process for new products only
12%
To select process for new products only
23%
To select processes for both new and legacy products
21%
Do not use QbD
23%
View Results
UPCOMING CONFERENCES

Programs for Investigational and Pre-Launch Drugs
Philadelphia, PA
July 17-18, 2013
Request Brochure

Strategic Pipeline Planning & Portfolio Valuation
Philadelphia, PA
August 13-14, 2013
Request Brochure

MES 2013 - Forum on Manufacturing Execution Systems
Philadelphia, PA
August 14-15, 2013
Request Brochure

Mobile Innovation for the Life Sciences Industry
Philadelphia, PA
August 20-21, 2013
Request Brochure

See All Conferences >>

Eric Langer Outsourcing Outlook Eric LangerOutsourcing's Modest Role as a Cost-Containment Strategy
Patricia Van Arnum Ingredients Insider Patricia Van ArnumIntellectual Property Battles in Solid-State Chemistry
Nathan Jessop Industry Insider Nathan Jessop Campaign Against Counterfeit Drugs Continues
Lynn Torbeck Statistical Solutions Lynn D. TorbeckCompositing Samples and the Risk to Product Quality
 More
Inadequate Access to Medicines Puts EU at Risk
FDA Offers Insight on QbD for Modified-Release Products
Global Biosimilars Market to Reach $2.445 Billion in 2013
Adapting to Change
AstraZeneca and Exco InTouch Collaborate to Augment Current COPD Pathways
FindPharma Custom Search
Source: Pharmaceutical Technology,
Click here