Developing a modified Pulsincap system - Pharmaceutical Technology

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Developing a modified Pulsincap system


Pharmaceutical Technology Europe
Volume 21, Issue 11

Conclusion

Pulsatile drug release during a 24h period, consistent with the requirements for chronopharmaceutical drug delivery, was achieved from insoluble gelatin capsules, in which microencapsulated DS was sealed by a hydrogel plug (guar gum, hydroxypropylmethylcellulose, sodium alginate, sodium carboxymethylcellulose). This modified Pulsincap dosage form could be beneficial to the chronotherapy of RA as it has demonstrated programmable, time and pHdependent, sitespecific drug release, and offers an effective controlledrelease alternative to traditional dosage forms that have been met with poor patient compliance.

Dr Gayatri C.Patel is Assistant Professor at the Department of Pharmaceutics Maliba Pharmacy College Gopal Vidyanagar, Bardoli-Mahuva Road, Surat-394350, Gujarat (India). Tel. +91 2625 255144,255882 Fax +91 2625 255882

Dr Madhabhai M. Patel is Principal and Head of Department of Pharmaceutics and Pharmaceutical Technology at Kalol Institute of Pharmacy (India).

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