Plastic Prefilled Syringes: A Better Fit for Autoinjector Systems - Pharmaceutical Technology

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Plastic Prefilled Syringes: A Better Fit for Autoinjector Systems
The authors describe the ways in which plastic prefilled syringes can be an alternative that provides consistent performance, protects drugs prone to degradation, and enhances patient safety.


Pharmaceutical Technology


Summary

Despite the fact that glass is still the predominant material, plastic prefilled syringes are gaining ground because of the many benefits associated with cyclic olefin polymer resins. Drug manufacturers that seek autoinjector technology for their products, particularly for biologicals and vaccines, should consult a vendor that understands primary container performance. Syringes' dimensions should be as consistent as possible, and the syringes should preferably be molded instead of formed, to help overcome the problem of break-force variability. Plastic syringes also can improve the safety of the delivery by eliminating tungsten or glue contamination. If a glass syringe is necessary, the autoinjector itself can be modified to aid the delivery process by registering the force on the strongest part of the syringe. This technique helps to overcome the dimensional variability of the glass prefilled syringe, reduce breakage, provide a consistent depth of injection, and create a reliable system that delivers the dose easily and effectively to the patient.

Douglas Stout* is director of strategic market development, and Vinod Vilivalam is director of strategic market and technical development for the Daikyo Crystal Zenith prefillable and vial platform, both at West, 101 Gordon Dr., Lionville, PA 19341, tel. 732.946.2929, fax 732.945.2189.

*To whom all correspondence should be addressed.

References

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