Summary
Despite the fact that glass is still the predominant material, plastic prefilled syringes are gaining ground because of the
many benefits associated with cyclic olefin polymer resins. Drug manufacturers that seek autoinjector technology for their
products, particularly for biologicals and vaccines, should consult a vendor that understands primary container performance.
Syringes' dimensions should be as consistent as possible, and the syringes should preferably be molded instead of formed,
to help overcome the problem of break-force variability. Plastic syringes also can improve the safety of the delivery by eliminating
tungsten or glue contamination. If a glass syringe is necessary, the autoinjector itself can be modified to aid the delivery
process by registering the force on the strongest part of the syringe. This technique helps to overcome the dimensional variability
of the glass prefilled syringe, reduce breakage, provide a consistent depth of injection, and create a reliable system that
delivers the dose easily and effectively to the patient.
Douglas Stout* is director of strategic market development, and Vinod Vilivalam is director of strategic market and technical development for the Daikyo Crystal Zenith prefillable and vial platform, both
at West, 101 Gordon Dr., Lionville, PA 19341, tel. 732.946.2929, fax 732.945.2189.
*To whom all correspondence should be addressed.
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