Understanding The Requirements For Effective Nasal Drug Delivery - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Understanding The Requirements For Effective Nasal Drug Delivery

Pharmaceutical Technology Europe
Volume 22, Issue 9


To achieve optimal product performance, nasal spray developers need to manipulate device and formulation parameters on the basis of detailed understanding. Laser diffraction is a valuable technique for accessing relevant information because it captures droplet size data in real time, enabling researchers to evaluate the impact of any change. The influence of formulation properties such as viscosity and device parameters, including actuation profile, spray pump mechanism and actuator orifice size, can be systematically studied to facilitate a knowledge-based approach, as the presented data show. The recommendation by the regulators of laser diffraction as a measurement technique, relevant across the complete product lifecycle, from development through to quality control, underlines its value.

Paul Kippax is Product Manager — Diffraction Products at Malvern Instruments Ltd., UK. Tel. +44 (0)1684 892 456

Julie Suman is President at NextBreath LLC, USA.

Gerallt Williams is Director, R&D Laboratory Services at AptarGroup SAS, France.


1. Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products — Chemistry, Manufacturing, and Controls Documentation (FDA, USA, July 2002). http://www.fda.gov/

2. Bioavailability and Bioequivalence Studies for Nasal Aerosols and Nasal Sprays for Local Action (FDA, USA, April 2003). http://www.fda.gov/

3. Guideline on the Pharmaceutical Quality of Inhalation and Nasal Products (European Medicines Agency, London, UK, June 2006). http://www.ema.europa.eu

4. Data on file at Malvern Instruments.


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
View Results
Eric Langerr Outsourcing Outlook Eric LangerTargeting Different Off-Shore Destinations
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAsymmetric Synthesis Continues to Advance
Jill Wechsler Regulatory Watch Jill Wechsler Data Integrity Key to GMP Compliance
Sean Milmo European Regulatory WatchSean MilmoExtending the Scope of Pharmacovigilance Comes at a Price
New FDA Team to Spur Modern Drug Manufacturing
From Generics to Supergenerics
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Ebola Outbreak Raises Ethical Issues
Better Comms Means a Fitter Future for Pharma, Part 2: Realizing the Benefits of Unified Communications
Source: Pharmaceutical Technology Europe,
Click here