Using Polymer Technology to Enhance Bioavailability - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Using Polymer Technology to Enhance Bioavailability
The authors review seven polymer classes that can be used to prepare solid-dispersion formulations.


Pharmaceutical Technology
pp. s37-s42

Conclusion

When developing solid-dispersion formulations of poorly soluble APIs, one must do the following: compare the API functional groups with the polymer functional groups, compare the API solubility parameters with polymer solubility parameters, and analyze the expected permeability of the API to determine which polymers to evaluate for solid-dispersion technology. The most soluble or most stable formulation should not necessarily always be chosen for further process development because many factors (e.g., API permeability window, polymer supply, polymer toxicology, physical product characteristics, and processing yields) can have a substantial impact on the final product. These issues must be considered before moving forward with product development.

Timothy Bee is a senior director and Mohammed Rahman* is a project leader/solid-dispersion scientist, both at International Specialty Products (ISP), tel. 410.910.7414,
, http://www.isppharmaceuticals.com/.

*To whom all correspondence should be addressed.

References

1. R.C. Rowe, P.J. Sheskey, and M.E. Quinn, Handbook of Pharmaceutical Excipients, 6th ed. (Pharmaceutical Press, Grayslake, IL, 2009)

2. G. Verreck et al., European Jrnl. of Pharma. Sci., 26, 349–358 (2005).

3. J.A. Quinn, Molecular Modeling Pro Plus, Norgwyn Montgomery Software, Version 6.2.5

4. K.A. Coppens, M.J. Hall, S.A. Mitchell, and M.D. Read, Pharm. Technol. 30 (1) 62–70 (2006).

5. Shin Etsu AQOAT Product Literature, Shin-Etsu Chemical Co. (Tokyo).

6. Shin Etsu, "Glass Transition Temperature of Cellulose Derivatives by TMA Method," (Shin-Etsu Chemical Co., April 2003).

7. Eastman C-A-P Enteric Coating Material Product Literature, Eastman Chemical Co. (Kingsport, TN, August 2003).

8. Evonik, "EUDRAGIT Application guidelines," Pharma Polymers, 10th ed. (Evonik Rohm GmbH, Essen, GermanN, July 2007).

9. Evonik Rohm GmbH, "Specifications and Test Methods for EUDRAGIT L100-55" (Evonik Rohm GmbH, Essen, Germany, Sept. 2007).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
26%
Oversee medical treatment of patients in the US.
12%
Provide treatment for patients globally.
10%
All of the above.
43%
No government involvement in patient treatment or drug development.
10%
Jim Miller Outsourcing Outlook Jim MillerCMO Industry Thins Out
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerFluorination Remains Key Challenge in API Synthesis
Marilyn E. Morris Guest EditorialMarilyn E. MorrisBolstering Graduate Education and Research Programs
Jill Wechsler Regulatory Watch Jill Wechsler Biopharma Manufacturers Respond to Ebola Crisis
Sean Milmo European Regulatory WatchSean MilmoHarmonizing Marketing Approval of Generic Drugs in Europe
FDA Reorganization to Promote Drug Quality
FDA Readies Quality Metrics Measures
New FDA Team to Spur Modern Drug Manufacturing
From Generics to Supergenerics
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Source: Pharmaceutical Technology,
Click here