Using Polymer Technology to Enhance Bioavailability - Pharmaceutical Technology

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Using Polymer Technology to Enhance Bioavailability
The authors review seven polymer classes that can be used to prepare solid-dispersion formulations.


Pharmaceutical Technology
pp. s37-s42

Conclusion

When developing solid-dispersion formulations of poorly soluble APIs, one must do the following: compare the API functional groups with the polymer functional groups, compare the API solubility parameters with polymer solubility parameters, and analyze the expected permeability of the API to determine which polymers to evaluate for solid-dispersion technology. The most soluble or most stable formulation should not necessarily always be chosen for further process development because many factors (e.g., API permeability window, polymer supply, polymer toxicology, physical product characteristics, and processing yields) can have a substantial impact on the final product. These issues must be considered before moving forward with product development.

Timothy Bee is a senior director and Mohammed Rahman* is a project leader/solid-dispersion scientist, both at International Specialty Products (ISP), tel. 410.910.7414,
, http://www.isppharmaceuticals.com/.

*To whom all correspondence should be addressed.

References

1. R.C. Rowe, P.J. Sheskey, and M.E. Quinn, Handbook of Pharmaceutical Excipients, 6th ed. (Pharmaceutical Press, Grayslake, IL, 2009)

2. G. Verreck et al., European Jrnl. of Pharma. Sci., 26, 349–358 (2005).

3. J.A. Quinn, Molecular Modeling Pro Plus, Norgwyn Montgomery Software, Version 6.2.5

4. K.A. Coppens, M.J. Hall, S.A. Mitchell, and M.D. Read, Pharm. Technol. 30 (1) 62–70 (2006).

5. Shin Etsu AQOAT Product Literature, Shin-Etsu Chemical Co. (Tokyo).

6. Shin Etsu, "Glass Transition Temperature of Cellulose Derivatives by TMA Method," (Shin-Etsu Chemical Co., April 2003).

7. Eastman C-A-P Enteric Coating Material Product Literature, Eastman Chemical Co. (Kingsport, TN, August 2003).

8. Evonik, "EUDRAGIT Application guidelines," Pharma Polymers, 10th ed. (Evonik Rohm GmbH, Essen, GermanN, July 2007).

9. Evonik Rohm GmbH, "Specifications and Test Methods for EUDRAGIT L100-55" (Evonik Rohm GmbH, Essen, Germany, Sept. 2007).


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