Using Polymer Technology to Enhance Bioavailability - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Using Polymer Technology to Enhance Bioavailability
The authors review seven polymer classes that can be used to prepare solid-dispersion formulations.

Pharmaceutical Technology
pp. s37-s42


When developing solid-dispersion formulations of poorly soluble APIs, one must do the following: compare the API functional groups with the polymer functional groups, compare the API solubility parameters with polymer solubility parameters, and analyze the expected permeability of the API to determine which polymers to evaluate for solid-dispersion technology. The most soluble or most stable formulation should not necessarily always be chosen for further process development because many factors (e.g., API permeability window, polymer supply, polymer toxicology, physical product characteristics, and processing yields) can have a substantial impact on the final product. These issues must be considered before moving forward with product development.

Timothy Bee is a senior director and Mohammed Rahman* is a project leader/solid-dispersion scientist, both at International Specialty Products (ISP), tel. 410.910.7414,

*To whom all correspondence should be addressed.


1. R.C. Rowe, P.J. Sheskey, and M.E. Quinn, Handbook of Pharmaceutical Excipients, 6th ed. (Pharmaceutical Press, Grayslake, IL, 2009)

2. G. Verreck et al., European Jrnl. of Pharma. Sci., 26, 349–358 (2005).

3. J.A. Quinn, Molecular Modeling Pro Plus, Norgwyn Montgomery Software, Version 6.2.5

4. K.A. Coppens, M.J. Hall, S.A. Mitchell, and M.D. Read, Pharm. Technol. 30 (1) 62–70 (2006).

5. Shin Etsu AQOAT Product Literature, Shin-Etsu Chemical Co. (Tokyo).

6. Shin Etsu, "Glass Transition Temperature of Cellulose Derivatives by TMA Method," (Shin-Etsu Chemical Co., April 2003).

7. Eastman C-A-P Enteric Coating Material Product Literature, Eastman Chemical Co. (Kingsport, TN, August 2003).

8. Evonik, "EUDRAGIT Application guidelines," Pharma Polymers, 10th ed. (Evonik Rohm GmbH, Essen, GermanN, July 2007).

9. Evonik Rohm GmbH, "Specifications and Test Methods for EUDRAGIT L100-55" (Evonik Rohm GmbH, Essen, Germany, Sept. 2007).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
View Results
Jim Miller Outsourcing Outlook Jim Miller Health Systems Raise the Bar on Reimbursing New Drugs
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerThe Mainstreaming of Continuous Flow API Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler Industry Seeks Clearer Standards for Track and Trace
Siegfried Schmitt Ask the Expert Siegfried SchmittData Integrity
Sandoz Wins Biosimilar Filing Race
NIH Translational Research Partnership Yields Promising Therapy
Clusters set to benefit from improved funding climate but IP rights are even more critical
Supplier Audit Program Marks Progress
FDA, Drug Companies Struggle with Compassionate Use Requests
Source: Pharmaceutical Technology,
Click here