Investigating the Influence of Glycosylation on Protein Conformation and Dynamics - Pharmaceutical Technology

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Investigating the Influence of Glycosylation on Protein Conformation and Dynamics
The authors review and discuss the influence of glycans on the conformation of a representative IgG1 biopharmceutical using H/DX-MS as an analytical tool.

Pharmaceutical Technology
Volume 34, pp. s12-s17


The authors would like to thank Dr. Helena Madden, Dr. Rohin Mhatre, and Dr. John R. Engen for helpful discussions and for critical reading of the manuscript.

Damian Houde* is a scientist, and Steven A. Berkowitz, is a principal investigator, both at Biogen Idec, Inc., 14 Cambridge Center, Cambridge, MA 02142, tel: 617.914.5841, fax: 617.679.3476.

*To whom all correspondence should be addressed.


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