Investigating the Influence of Glycosylation on Protein Conformation and Dynamics - Pharmaceutical Technology

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Investigating the Influence of Glycosylation on Protein Conformation and Dynamics
The authors review and discuss the influence of glycans on the conformation of a representative IgG1 biopharmceutical using H/DX-MS as an analytical tool.


Pharmaceutical Technology
Volume 34, pp. s12-s17

15. S.W. Englander and L. Mayne, Annu. Rev. Biophys. Biomol. Struct. 21, 243–265 (1992).

16. V. Katta and B.T. Chait, Rapid Comm. Mass Spec. 5 (4), 214–217 (1991).

17. Z. Zhang and D.L. Smith, Protein Sci. 2 (4), 522–531 (1993).

18. S.W. Englander and N.R. Kallenbach, Q. Rev. Biophys. 16 (4), 134 (1983).

19. T.E. Wales and J.R. Engen, Mass Spectrom. Rev. 25 (1), 158–170 (2006).

20. A.N. Hoofnagle, K.A. Resing, and N.G. Ahn, Annu. Rev. Biophys. Biomol. Struct. 32, 1–25 (2003).

21. J.G. Mandell, A.M. Falick, and E.A. Komives EA, Anal. Chem. 70 (19), 3987–3995 (1998).

22. O.H. Brekke and I. Sandlie, Nat. Rev. Drug Discov. 2 (1), 52–62 (2003).

23. O. Leav, Nat. Rev. Immunol. 10 (5), 297–297 (2010).

24. D. Houde et al., Anal. Chem. 81 (7), 2644–2651 (2009).

25. H.E. Chadd and S.M. Chamow, Curr. Opin. Biotechnol. 12 (2), 188–194 (2001).

26. Y. Mimura et al., Mol. Immunol. 37 (12–13), 697–706 (2000).

27. D. Houde , Mol. Cell. Proteomics 9 (8), 1716–1728 (2010).

28. Y. Yamaguchi et al., Biochem. Biophys. Acta 1760 (4), 693–700 (2006).

29. P. Sondermann et al., Nature 406 (6793), 267–273 (2000).

30. H. Liu and C.G. Bulseco, Immunol. Lett. 106 (2), 144–153 (2006).

31. S. Krapp et al., .J Mol. Biol. 325 (5), 979–989 (2003).

32. A. Okazaki et al., J. Mol. Biol. 336 (5), 1239–1249 (2004).

33. S. Radaev et al., J. Biol. Chem. 276 (19), 16469–16477 (2001).

34. D. Shental–Bechor and Y. Levy, Curr. Opin. Struct. Biol. 19 (5), 524–533 (2009).

35. K.D. Rand et al., Anal. Chem. 81 (14), 5577–5584 (2009).

36. E.O. Saphire et al., Science 293 (5532), 1155–1159 (2001).


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