Transdermal Delivery of Vaccines and Therapeutic Proteins - Pharmaceutical Technology

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Transdermal Delivery of Vaccines and Therapeutic Proteins
The author reviews advances in technology that may soon allow transdermal delivery of two of the fastest growing drug classes on the pharmaceutical market. This article is part of a special Drug Delivery issue.

Pharmaceutical Technology
pp. s14-s20


1. E. N. Marieb and K. Hoehn, Human Anatomy & Physiology, (Benjamin Cummings, San Francisco, CA, 8th ed., 2010).

2. J. Nicolas and B. Guy, Expert Reviews Vaccine 7 (8), 1201–1214 (2008).

3. I. M. Braverman, JID Symposium Proceedings 5 (1), 3–9 (2000).

4. A. Laurent et al., Vaccine 25, 6423–6430 (2007).

5. M. Skobe and M. Detmar, JID Symposium Proceedings 5 (1), 14–19 (2000).

6. P. S. Mortimer et al., Jrnl. of Invest. Derm. 95 (6), 677–682 (1990).

7. D. Lubach, W. Ludemann, and D. Berens Von Rautenfeld, Br. J. Dermatol. 135 (5), 733–737 (1996).

8. J. Hickling and R. Jones, WHO PATH, 1–17 (Aug. 27, 2009).

9. G. Rozis et al., Immunology 124, 329–338 (2008).

10. L. Tuft, E.M. Yagle, and S. Rogers, Laboratories of the Graduate Hospital, University of Pennsylvania and the Research Institute of Cutaneous Medicine, pp. 99–110 (Apr. 20, 1931)

11. R. T. Kenney et al., The New Engl. Jrnl. of Med. 351 (22), 2295–2301 (2004).

12. K. J. Hansen and M. A, Tomai, "Highly Efficient Transdermal Delivery of Vaccines," presented at Modern Vaccine Adjuvants and Delivery Systems, Vienna, Austria, 2009.

13 S. K. Garg et al., Diabetes Technol. & Therapeut. 11, S5–S16, (2009)

14. S.A. Shoyele, and A. Slowey, Intern. Jrnl. of Pharmaceut. 314, 1–8, (2006)

15. K. Alitalo, T. Tammela, and T. V. Petrova, Nature 438 (15), 946–953 (2005).

16. M. S. Pepper and M. Skobe, Jrnl. of Cell Biol. 163 (2), 209–213 (2003).

17. W. N. Charman, V. J. Stella, Lymphatic Transport of Drugs, (CRS Press Inc, Boca Raton, FL, 1992)

18. L. V. Leak, Jrnl. of Cell Biol. 50, 300–323 (1971).

19. L.V. Leak and J. F. Burke, Am. J. Anat. 118, 785–810 (1966).

20. C. J. H. Porter and S. A. Charman, Jrnl. of Pharmaceut. Sci. 89 (3), 297–310 (2000).

21. A. Supersaxo et al., Pharm. Res. 5 (8), 472–476 (1988).

22. W. Morozowich et al., Proceed. Intern. Symp. Control. Rep. Bioact. Mater. 17, 185–186 (1990).

23. S. Mutanishi, T. Fujita, M. Mruakami, and A. Yamamoto, Jrnl. of Contr. Rel. 46, 157–164 (1997).


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