Technical Note: The Effect of Alcoholic Beverages on Sustained Release - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Technical Note: The Effect of Alcoholic Beverages on Sustained Release
The authors evaluated the effect of alcoholic beverages on the release profiles of sustained-release dosage forms containing metformin and diclofenac.

Pharmaceutical Technology
Volume 34, Issue 12, pp. 47-49

Table I: F2 values of dissolution data.
The significant changes in release pattern are further confirmed by low F2 values. The similarity factor F2, as defined by the US Food and Drug Administration, is a logarithmic reciprocal square-root transformation of one plus the mean squared (i.e., the average sum of squares) differences of drug percent dissolved between the test and reference products (5). Table I compares the F2 values for all dissolutions in alcoholic beverages with those in water. The results clearly indicate the effect of alcoholic beverages on in vitro drug release.


The authors concluded that the release of the instant-release formulations was faster in Kingfisher Strong beer, Mild beer, rum, and 40% alcohol than it was in water. The difference may be attributable to the volume of the alcoholic beverages, rather than to their strength. The drug release of the sustained-release formulations was faster in 40% alcohol and in rum than it was in water. The authors concluded that the consumption of alcoholic beverages should be avoided during treatment with sustained-release formulations of metformin and diclofenac to prevent dose dumping.

Anagha Joshi* is a doctoral student at Bharati Vidyapeeth University's Poona College of Pharmacy and assistant professor of pharmaceutical chemistry at Indira College of Pharmacy, Pune, Maharashtra, India,
. Shivajirao S. Kadam is vice-chancellor of Bharati Vidyapeeth University Pune, Maharashtra,India, and Aatmaram P. Pawar is a professor of pharmaceutics at Bharati Vidyapeeth University Pune, Maharashtra, India.

*To whom all correspondence should be addressed.

Submitted: Feb. 13, 2010. Accepted: Apr. 5, 2010.


1. L.A. Bennett et al., Alcohol Health Res. World 22 (4), 243–252 (1998).

2. R.J. Meyer and A.S. Hussain, Proceedings of FDA's Advisory Committee For Pharmaceutical Science meeting (Rockville, MD, 2005), p. 2.

3. Indian Pharmacopoeia (Controller of Publications, New Delhi, India, 2007), p. 1020.

4. Goodman and Gilman's The Pharmacological Basis of Therapeutics, J.G. Hardman, L.E. Limbird, and A.G. Gilman, Eds. (McGraw-Hill, New York, 10th ed., 2001), pp. 644–646.

5. M.C. Gohel and M.K. Panchal, Dissol. Technol. 9 (1), 1–5 (2002).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatcchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Obama Administration Halts Attack on Medicare Drug Plans
Source: Pharmaceutical Technology,
Click here