Printable Medicines: A Microdosing Device For Producing Personalized Medicines - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Printable Medicines: A Microdosing Device For Producing Personalized Medicines
The authors describe a new method for the production of personalised medicines involving the direct printing of drug solutions or suspensions containing APIs and excipients onto edible paper carrier materials utilising ultra-precise microdrop printing technology. The approach allows ultra-precise dosing of the API according to the specific requirements of each individual patient and is suited for highly active low-dose drugs.


Pharmaceutical Technology Europe
Volume 23, Issue 1

Conclusions


The authors say...
We present a method for manufacturing a medication using microdrop printing technology, which offers new possibilities in the fields of personalised medicine, the production of lowdosage forms, including process verification, documentation and labelling, and the individual adjustment of the medication with respect to multidosing and controlled drug release. The system has already been extensively tested, provides an innovative mechanism to prevent counterfeit medications and seems to be suitable for the formulation of highly potent and active drug substances.

Christine Voura is Senior Researcher from the Research Center Pharmaceutical Engineering GmbH, Graz, Austria.

Michael M. Gruber is Junior Researcher from the Research Center Pharmaceutical Engineering GmbH, Graz, Austria.

Nina Schroedl is Technician from the Research Center Pharmaceutical Engineering GmbH, Graz, Austria.

Daniela Strohmeier is Technician from the Research Center Pharmaceutical Engineering GmbH, Graz, Austria.

Bernhard Eitzinger is R&D Manager from Dr. Franz Feurstein GmbH, Traun, Austria.

Wolfgang Bauer is Professor from the Institute for Paper, Pulp and Fibre Technology, Graz University of Technology, Graz, Austria.

Guenter Brenn is Professor from the Institute of Fluid Mechanics and Heat Transfer, Graz University of Technology, Graz, Austria.

Johannes G. Khinast is Professor from the Research Center Pharmaceutical Engineering GmbH, Graz/Austria and the Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria.

Andreas Zimmer is the article's corresponding author and Professor from the the Institute of Pharmaceutical Sciences, Karl-Franzens University of Graz, Graz, Austria.
Tel. +43 316 380 8880

References

1. W.E. Katstra et al., Journal of Controlled Release, 66(1), 1–9 (2000).

2. Patent Application WO 2010/012470 A1: A system and method for manufacturing a medication (2010).

3. W. Meyer, Farbe und Lack, 112(3), (2006).

4. E.R. Lee, Methods of Generating Monodisperse Microdrops. Microdrop Generation (CRC Press LCC, Florida, USA, 2003) pp 15–32.

5. BD. Glass and A. Haywood, J. Pharm. Pharmaceut. Sci., 9(3), 398–426 (2006).

6. T.J. Nicolson et al., Trends in Pharmacological Sciences, 31(3), 108–114 (2010).

7. FDA, Evaluation of Gender Differences in Clinical Investigations — Information Sheet. Clinical Trial Guidance (1998). http://www.fda.gov/

8. H. Ahmed and N. Shah, American Pharmaceutical Review, 3(3) (2000).

9. S. Yang and J.R.G. Evans, Powder Technology, 178(1), 56–72 (2007).

10. R. Mitchell and D. Edwards, Pharmaceutical Technology Europe, 21(7), 22–24 (2009).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
27%
Attracting a skilled workforce
27%
Obtaining/maintaining adequate financing
14%
Regulatory compliance
32%
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Report: Pfizer Makes $101 Billion Offer to AstraZeneca
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Source: Pharmaceutical Technology Europe,
Click here