Evaluation and Characteristics of a New Direct Compression Performance Excipient - Pharmaceutical Technology

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Evaluation and Characteristics of a New Direct Compression Performance Excipient
The authors investigated the tableting properties of PanExcea MHC300G, a high-performance excipient.

Pharmaceutical Technology
Volume 35, Issue 3


1. D. McCormik, Pharm. Technol. 5, (4) 52–62 (2005) .

2. N.A. Armstrong, Encyclopedia of Pharmaceutical Technology, Informa Healthcare USA, Inc. (New York, Third Edition, 2006).

3. H.G. Kristensen and T. Schaefer, Drug Dev. and Ind. Pharm. 13, 803–872 (1987).

4. A.J. Hlinak, et al., J. of Pharm. Innov. 1, 12–17 (2006).

5. M. Jivraj, L.G. Martini, C.M. Thomson, Pharm. Sci. and Technol. Today, 3, 58–63 (2000).

6. R.J. Roberts, R.C. Rowe, Int. J. of Pharm. 36, 205–209 (1987).

7. K. van der Voort Maarschalk, G.K. Bolhuis, Pharm. Technol. 23, 34–46 (1999).

8. K. van der Voort Maarschalk et al., Int. J. of Pharm. 151, 27–34 (1997).

9. G.K. Bolhuis, N.A. Armstrong, Pharm. Dev. and Technol. 11, 111–124 (2006).

10. G. Bubb, Tablets and Capsules, 7, (2007).

11. IPEC–Americas, Frequently Asked Questions web page, http://ipecamericas.org/about/faqs/, accessed Feb. 16, 2011.

12. N. Deorkar, Tablets and Capsules, 8, 22–26 (2008).

13. L. Mīinea, J. Farina, M. Kallam, N. Deorkar, Pharm. Processing, Feb. 2009, http://www.pharmpro.com/Articles/2009/03/A-New-World-of-Excipients-for-Oral-Solid-Dosage-Formulation/, accessed Feb. 16, 2011.

14. S.K. Nachaegari, A.K. Bansal, Pharm. Technol. 28 (1) 52–64 (2004).

15. M.C. Gohel, P.D. Jogani, J. of Pharm. and Pharm. Sci. 8, 76–93 (2005).

16. C. Moreton, "Functionality and Performance of Excipients in a Quality-by-Design World: Parts 1–6," a series of papers published in each issue of vol. 12 of American Pharmaceutical Review (2009).

17. N. Deorkar, J. Farina, L. Mīinea, S. Randive, "Directly Compressible High Functionality Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof" PCT/US2008/011555 (Oct. 2008).

18. Mallinckrodt Baker, product profile for PanExcea MHC300G, http://www.mallbaker.com/Literature/Documents/PanExcea%20IR%20Product%20Profile%20Lit7001.pdf, accessed Feb. 16, 2011.

19. L. Mīinea, R. Mehta, J. Farina, N. Deorkar, "Granular Excipients Based on Microcrystalline Cellulose: DOE study of a lab-based scale high shear granulation process," poster presentation at "Excipient Fest Americas", (Puerto Rico, April 2008).

20. USP 34–NF 29 General Chapter <1174> "Powder Flow."

21. Carr, R. L. Chem. Eng. 72,163–168, 1965.

22. Hosokawa Micron, product profile for Hosokawa Micron Powder Characteristics Tester PT-S, http://www.hosokawa.co.uk/powdtest.php, accessed Feb. 16, 2011.

23. S.I.F. Badawy, D.B. Gray, M.A. Hussain, Pharm. Res. 23, 634–640 (2006).

24. T. Suzuki et al., J. of Pharm. and Pharmacol. 53, 609–616 (2001).

25. C.K. Tye, C. Sun, G.E. Amidon, J. of Pharm. Sci. 94, 465–472 (2005).


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