Interphex on Tap - Pharmaceutical Technology

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PharmTech Europe

Interphex on Tap
The 2011 show presents ideas for package designs and equipment options for packaging lines.

Pharmaceutical Technology
Volume 35, Issue 3, pp. 44-48

Track and trace

The blow-fill-seal process aseptically fills and seals the container while it's still in the mold. Molds frequently are designed to produce two or more containers simultaneously. (IMAGE COURTESY OF ROMMELAG)
A track-and-trace system conveys, uniquely marks, and verifies 450 pharmaceutical packages per minute so that individual packages can be tracked through each phase of the packaging line and throughout the distribution system. Positioned immediately downstream of a cartoner, the system conveys each carton past a noncontact laser or thermal inkjet printhead that applies a two-dimensional barcode, batch number, lot number, production date, expiration date, and other desired information, as well as a unique number for mass serialization. The unique, random identifier, known only to the pharmaceutical producer, prevents counterfeiting and facilitates accurate traceability.

Using high-resolution vision technology, the system inspects and verifies printed data and label alignment and records information in an internal database. An air knife blows non-readable cartons into a secure reject bin equipped with a sensor to confirm that a reject has been accepted. A quick-change mechanism expedites adjustments for various carton sizes. Windows-based operation is controlled at the swing-arm-mounted, 17-in. (432-mm) touch screen. Line-management software manages individual or multiple vision sensors, coding devices, checkweighers, and associated equipment across automated production and packaging lines (Line Director Production Line Management Software, Crest Solutions).

End-ported biocontainers like this one from Meissner Filtration Products meet the growing demand for single-use systems. (PHOTO IS COURTESY OF MEISSNER FILTRATION PRODUCTS)
The track-and-trace system also uses database-management software to simplify implementation of product traceability (Protrack real-time database management software, Crest Solutions). Employed as a stand-alone system or as a component of an integrated line, the coding and data-collection system enables paperless compliance with existing and upcoming national and international track-and-trace regulations, including Brazil ANVISA, TS (Turkey), French Coding, California ePedigree, Good Automated Manufacturing Practice 5, and 21 CFR Part 11 (PharmaMarker 450, Eisai Machinery USA).

Barrier material

A foil lamination with a frangible sealant layer keeps product components isolated from each other until they reach the point of use. Breaking the seal permits the contents of each compartment to mix or dispense together. Two distinct heat-seal profiles allow the sealant to produce a permanent seal and a frangible seal. Applications include skin applicators and dual-component products (PerfecPharm P702, Perfecseal).


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