Methods for the Automated Manufacturing of an Autologous Dendritic-Cell Immunotherapy - Pharmaceutical Technology

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Methods for the Automated Manufacturing of an Autologous Dendritic-Cell Immunotherapy
The authors developed automated equipment that uses functionally closed disposables to perform cellular and ribonucleic processing.


Pharmaceutical Technology
Volume 35, pp. s12-s17

Conclusion

These prototypes demonstrated the feasibility of this automated approach. The automated equipment and the associated disposable sets or components provides a platform technology to enable commercial manufacturing of complex autologous DC immunotherapies.

Tamara T. Monesmith is a director of manufacturing and process development at Argos Therapeutics, 4233 Technology Dr., Durham, NC 27704, tel. 919.287.6300, fax 919.287.6301,
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References

1. J. Harris et al., Biochim. Biophys. Acta 1724 (1-2), 127–136 (2005).

2. I. Tcherepanova et al., PLoS One 1 (e1489), 1–10 (2008).

3. S.R. Bennett et al., Nature 393 (6684), 478–480 (1998).

4. J.P. Ridge, R.F. Di, and P. Matzinger, Nature 393 (6684), 474–478 (1998).

5. S.P. Schoenberger et al., Nature 393 (6684), 480–483 (1998).

6. P.T. Coates et al., Expert Rev. Mol. Med. 4 (3),1–21 (2002).

7. M.A. DeBenedette et al., J. Immunother. 34 (1), 45–57 (2011).

8. I.Y. Tcherepanova et al., BMC Mol. Biol. 9 (90), 1–13 (2008).

9. D.M. Calderhead et al., J. Immunother. 31 (8), 731-741 (2008).

10. M.A. DeBenedette et al., J. Immunol. 181 (8), 5296–5305 (2008).

11. A. Jemal et al., CA Cancer J. Clin. 60 (5), 277–300 (2010).

12. S.A. Karumanchi, J. Merchan, and V.P. Sukhatme, Curr. Opin. Nephrol. Hypertens. 11 (1), 37–42 (2002).

13. National Cancer Institute, SEER Cancer Statistics Review, 1975–2007, S.F. Altekruse et al., Eds. (NCI, Bethesda, MD, 2010).

14. K.J. Pienta and D.C. Smith, CA Cancer J. Clin. 55 (5), 300–318 (2005).


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