Improving API Synthesis - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Improving API Synthesis
O-arylation and O-alkylation, a one-pot protein synthesis, a combined approach in continued and chemocatalysis, and green-chemistry applications are the target of some recent advances in API synthesis.

Pharmaceutical Technology
Volume 35, Issue 8, pp. 52-56


1. N. Yoshikawa et al., Org. Process. Res. Dev. 15 (4), 824–830 (2011).

2. K. Mandal and S.B.H. Kent, Total Chemical Synthesis of Biologically Active Vascular Endothelial Growth Factor Agnew. Chem. Int. Ed, online, DOI 10.1002/anie.201103237, July 8, 2011.

3. L.K. Wolf, Chem. & Eng. News 89 (29), 27–28 (2011).

4. T. Noel et al., Suzuki–Miyaura Cross-Coupling Reactions in Flow: Multistep Synthesis Enabled by a Microfluidic Extraction, Agnew. Chem. Int. Ed. online, DOI: 10.1002/anie.201101480, May 17, 2011.

5. S.R. Ritter, Chem. & Eng. News 89 (23), 39 (2011).

6. P. Van Arnum, Pharm. Technol . 34 (12) 40–42 (2010).

7. N. Korman et al., API Synthesis, Formulation Development, and Manufacturing, asupplement to Pharm. Technol., s32–s36 (2010).

8. P. Li and S. L. Buchwald, Continuous-Flow Synthesis of 3,3-Disubstituted Oxindoles by a Palladium-Catalyzed a-Arylation/Alkylation Sequence, Agnew. Chem. Int. Ed. online, DOI: 10.1002/anie.201102401, June 7, 2011.

9. J.P. McMullen and K.F. Jensen, Org. Process Res. Dev. 14 (5), 1169–1176 (2010).

10. K.F. Jensen et al., Ind. Eng. Chem. Res. 49 (22), 11310–11320 (2010).

11. EPA, Presidential Green Chemistry Challenge Awards Program: Summary of 2011 Award Entries and Recipients (Washington, DC, June 2011).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
View Results
Eric Langerr Outsourcing Outlook Eric LangerRelationship-building at Top of Mind for Clients
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerRisk Reduction Top Driver for Biopharmaceutical Raw Material Development
Jill Wechsler Regulatory Watch Jill Wechsler Changes and Challenges for Generic Drugs
Faiz Kermaini Industry Insider Faiz KermainiNo Signs of a Slowdown in Mergers
Ebola Outbreak Raises Ethical Issues
Better Comms Means a Fitter Future for Pharma, Part 2: Realizing the Benefits of Unified Communications
Better Comms Means a Fitter Future for Pharma, Part 1: Challenges and Changes
Sandoz Wins Biosimilar Filing Race
NIH Translational Research Partnership Yields Promising Therapy
Source: Pharmaceutical Technology,
Click here