Improving API Synthesis - Pharmaceutical Technology

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PharmTech Europe

Improving API Synthesis
O-arylation and O-alkylation, a one-pot protein synthesis, a combined approach in continued and chemocatalysis, and green-chemistry applications are the target of some recent advances in API synthesis.

Pharmaceutical Technology
Volume 35, Issue 8, pp. 52-56


1. N. Yoshikawa et al., Org. Process. Res. Dev. 15 (4), 824–830 (2011).

2. K. Mandal and S.B.H. Kent, Total Chemical Synthesis of Biologically Active Vascular Endothelial Growth Factor Agnew. Chem. Int. Ed, online, DOI 10.1002/anie.201103237, July 8, 2011.

3. L.K. Wolf, Chem. & Eng. News 89 (29), 27–28 (2011).

4. T. Noel et al., Suzuki–Miyaura Cross-Coupling Reactions in Flow: Multistep Synthesis Enabled by a Microfluidic Extraction, Agnew. Chem. Int. Ed. online, DOI: 10.1002/anie.201101480, May 17, 2011.

5. S.R. Ritter, Chem. & Eng. News 89 (23), 39 (2011).

6. P. Van Arnum, Pharm. Technol . 34 (12) 40–42 (2010).

7. N. Korman et al., API Synthesis, Formulation Development, and Manufacturing, asupplement to Pharm. Technol., s32–s36 (2010).

8. P. Li and S. L. Buchwald, Continuous-Flow Synthesis of 3,3-Disubstituted Oxindoles by a Palladium-Catalyzed a-Arylation/Alkylation Sequence, Agnew. Chem. Int. Ed. online, DOI: 10.1002/anie.201102401, June 7, 2011.

9. J.P. McMullen and K.F. Jensen, Org. Process Res. Dev. 14 (5), 1169–1176 (2010).

10. K.F. Jensen et al., Ind. Eng. Chem. Res. 49 (22), 11310–11320 (2010).

11. EPA, Presidential Green Chemistry Challenge Awards Program: Summary of 2011 Award Entries and Recipients (Washington, DC, June 2011).


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