Another folded-wallet design can be assembled semiautomatically or automatically. The booklike configuration provides ample
space for product information and vivid graphics (CRx Pack, Pharma Packaging Solutions, a division of Carton Service).
Other designs bring CR protection to injection-molded containers. Designed to be reusable, a recyclable hinged container can
be sized and shaped to hold vials, blisters, aerosols, autoinjectors, patches, mists, pumps, and syringes. Releasing the lid
requires two hands, one putting pressure in one area on the base of the container, and the other pressing down on latches
on opposite ends of the integral lid. A version of the F = 1-rated container that holds multiple blisters could be used by
pharmacies for prescriptions (Medi-Lock CR Container, Intini).
A related two-piece container dispenses doses singly while providing F = 1 protection. It can be sized to handle virtually
any tablet and is compatible with high-speed, automated filling lines (Medi-Lock Top Lock Slider Pack, Intini).
Tube packaging also has CR options. One tiny cap for single-dose tubes also offers tamper-evident protection. Like many CR
concepts, the closure requires a dual movement. The outer cap rotates freely unless it is pushed in to interlock with the
inner cap. Pressing and turning releases an inner pin and opens the tube at a defined breaking point, while the cap remains
on the tube body during dispensing. An ergonomic nozzle enables precise application of the liquid or cream without allowing
the contents to be contaminated. The design is certified as CR and suitable for adults according to testing carried out in
accordance with 16 CFR 1700.20 and EN 14375. Applications include topical treatments, dietary supplements, concentrates or laboratory substances,
product samples, and travel-size products (Twist'n'Use CR Polyfoil tube, Neopac).
For larger tubes, CR closures are available in a diameter of 18 mm (CR Tube-Lok closure, Berry Plastics). For on-the-go applications,
a small integrated push-and-turn closure–vial combination holds a short stack of pills. It's offered in 16-mm or 20-mm diameters
(Pursepak package, Berry Plastics).
Hallie Forcinio is Pharmaceutical Technology's Packaging Forum editor, 4708 Morningside Drive, Cleveland, OH 44109, tel. 216.351.5824, fax 216.351.5684, firstname.lastname@example.org