Controlled Release from Porous Platforms - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Controlled Release from Porous Platforms
The authors present a method for controlling the release of therapeutics by applying a plasma polymer layer to the surface of porous materials.

Pharmaceutical Technology
Volume 35, Issue 8, pp. 68-71


The authors described a method for controlled release of therapeutics from porous materials that has the potential to be applied to various therapeutics and types of porous materials. The method involves the application of a plasma-polymer layer on top of porous materials, and the thickness of this layer controls release kinetics. Athough the current study emphasizes plasma polymerization as a tool to reduce pore diameter at the surface, future work should consider the influence of the plasma polymer's physical properties, such as hydrophilicity, on drug release. The ability of plasma polymerization to provide films of various physical and chemical properties provides enormous flexibility for fine tuning drug-release platforms to suit various drugs and applications.

Spomenka Simovic is a doctor of colloid chemistry and pharmaceutics, Dusan Losic is associate professor of nanostructured materials, and Krasimir Vasilev* is an Australian Future fellow, all at the University of South Australia, Mawson Lakes Campus, 5095 Mawson Lakes, South Australia, fax: +61 8 830 25689,

*To whom all correspondence should be addressed.

Submitted: Feb. 17, 2011. Accepted: May 13, 2011


1. C.T. Kresge et al., Nature 359, 710–712 (1992).

2. J.S. Beck et al., J. Am. Chem. Soc. 114 (27), 10834–10843 (1992).

3. M. Vallet-Regi et al., Chem. Mater. 13 (2), 308–311 (2001).

4. M. Vallet-Regi, F. Balas, and D. Arcos, Angew. Chem. Int. Ed. 46, 7548–7558 (2007).

5. K.C. Popat et al., Biomater. 28 (21), 3188–3197 (2007).

6. M. Vallet-Regi, Chem. Eur. J. 12, 5934–5943 (2006).

7. I. Izquierdo-Barba and M. Vallet-Regi, J. Nanomater. 1, 1–14, (2008).

8. L. Peng et al., Biomater. 30 (7), 1268–1272 (2009).

9. L. Peng et al., Nano Lett. 9 (5), 1932-1936 (2009).

10. K.E. La Flamme et al., Cell Transplant. 16, 765–774 (2007).

11. K.E. La Flamme et al., Biomater. 28 (16), 2638–2645 (2007).

12. E.E. Leary Swan, K.C. Popat, and T.A. Desai, Biomater. 26 (14), 1969–1976 (2005).

13. K.C. Popat et al., Biomater. 26 (22), 4516–4522 (2005).

14. H. Masuda and K. Fukuda, Science 268, 1466–1468 (1995).

15. P. Costa and J. M. Sausa-Lobo, Eur. J. Pharm. Sci. 13 (2), 123–133 (2001).

16. S. Simovic, D. Losic, and K. Vasilev. Chem. Commun. 46, 1317–1319 (2010).

17. K. Vasilev et al., Chem. Commun. 24, 3600–3602 (2009).

18. A.J. Beck et al., Tissue Eng. 7 (4), 441–456 (2003).

19. K. Vasilev et al., Nano Lett. 10 (1), 202–207 (2010).

20. D. Losic et al., Nanotechnol. 19, (2008).

21. F. Balas et al., J. Am. Chem. Soc. 128, 8116–8117 (2006).

Citation: When referring to this article, please cite it as "S. Simovic; D. Losic; K. Vasilev, "Controlled Release from Porous Platforms," Pharmaceutical Technology 35 (8) 68-71(2011)."


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatcchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Obama Administration Halts Attack on Medicare Drug Plans
Source: Pharmaceutical Technology,
Click here